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J. Clin. Med. 2016, 5(7), 63; doi:10.3390/jcm5070063

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

1
Ludwig Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, SE 751 24 Uppsala, Sweden
2
Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, SE 751 23 Uppsala, Sweden
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrei Turtoi
Received: 10 May 2016 / Revised: 22 June 2016 / Accepted: 22 June 2016 / Published: 29 June 2016
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
View Full-Text   |   Download PDF [1392 KB, uploaded 29 June 2016]   |  

Abstract

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help embryonic cells to generate migratory descendants that populate new sites and establish the distinct tissues in the developing embryo. The mesenchymal descendants of diverse epithelia also participate in the wound healing response of adult tissues, and facilitate the progression of cancer. EMT can be induced by several extracellular cues in the microenvironment of a given epithelial tissue. One such cue, transforming growth factor β (TGFβ), prominently induces EMT via a group of specific transcription factors. The potency of TGFβ is partly based on its ability to perform two parallel molecular functions, i.e. to induce the expression of growth factors, cytokines and chemokines, which sequentially and in a complementary manner help to establish and maintain the EMT, and to mediate signaling crosstalk with other developmental signaling pathways, thus promoting changes in cell differentiation. The molecules that are activated by TGFβ signaling or act as cooperating partners of this pathway are impossible to exhaust within a single coherent and contemporary report. Here, we present selected examples to illustrate the key principles of the circuits that control EMT under the influence of TGFβ. View Full-Text
Keywords: epithelial-mesenchymal transition; signal transduction; transcription factor; transforming growth factor β; tumor invasiveness epithelial-mesenchymal transition; signal transduction; transcription factor; transforming growth factor β; tumor invasiveness
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moustakas, A.; Heldin, C.-H. Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition. J. Clin. Med. 2016, 5, 63.

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