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J. Clin. Med. 2016, 5(9), 76; doi:10.3390/jcm5090076

Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity

Department of Biology, Hampden-Sydney College, Hampden-Sydney, VA 23943, USA
Academic Editor: Andrei Turtoi
Received: 20 July 2016 / Revised: 26 August 2016 / Accepted: 29 August 2016 / Published: 31 August 2016
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
View Full-Text   |   Download PDF [1339 KB, uploaded 31 August 2016]   |  

Abstract

TGFβ1 is a pleiotropic cytokine that exhibits a variety of physiologic and immune regulatory functions. Although its influence on multiple cell types is critical for the regulation of numerous biologic processes in the host, dysregulation of both TGFβ1 expression and activity is frequently observed in cancer and contributes to various aspects of cancer progression. This review focuses on TGFβ1’s contribution to tumor immune suppression and escape, with emphasis on the influence of this regulatory cytokine on the differentiation and function of dendritic cells and T cells. Clinical trials targeting TGFβ1 in cancer patients are also reviewed, and strategies for future therapeutic interventions that build on our current understanding of immune regulation by TGFβ1 are discussed. View Full-Text
Keywords: cancer; TGFβ1; dendritic cell; T cell; immune suppression; immunotherapy cancer; TGFβ1; dendritic cell; T cell; immune suppression; immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hargadon, K.M. Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity. J. Clin. Med. 2016, 5, 76.

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