Next Article in Journal
Preliminary Analysis of the Expression of Selected Proangiogenic and Antioxidant Genes and MicroRNAs in Patients with Non-Muscle-Invasive Bladder Cancer
Next Article in Special Issue
New Insights into the Crossroads between EMT and Stemness in the Context of Cancer
Previous Article in Journal / Special Issue
Homeostatic Signaling by Cell–Cell Junctions and Its Dysregulation during Cancer Progression
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2016, 5(2), 27; doi:10.3390/jcm5020027

Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease

Division of Cardiothoracic Surgery, University of Southern California, Los Angeles, CA 90027, USA
*
Author to whom correspondence should be addressed.
Academic Editor: David L. Brown
Received: 21 November 2015 / Revised: 22 January 2016 / Accepted: 3 February 2016 / Published: 19 February 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [510 KB, uploaded 19 February 2016]   |  

Abstract

The epicardium is an epithelial monolayer that plays a central role in heart development and the myocardial response to injury. Recent developments in our understanding of epicardial cell biology have revealed this layer to be a dynamic participant in fundamental processes underlying the development of the embryonic ventricles, the coronary vasculature, and the cardiac valves. Likewise, recent data have identified the epicardium as an important contributor to reparative and regenerative processes in the injured myocardium. These essential functions of the epicardium rely on both non-cell autonomous and cell-autonomous mechanisms, with the latter featuring the process of epicardial Epithelial-to-Mesenchymal Transition (EMT). This review will focus on the induction and regulation of epicardial EMT, as it pertains to both cardiogenesis and the response of the myocardium to injury. View Full-Text
Keywords: epicardium; epithelial-to-mesenchymal transition; heart development epicardium; epithelial-to-mesenchymal transition; heart development
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Krainock, M.; Toubat, O.; Danopoulos, S.; Beckham, A.; Warburton, D.; Kim, R. Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease. J. Clin. Med. 2016, 5, 27.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top