Next Article in Journal
Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
Next Article in Special Issue
Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
Previous Article in Journal
MicroRNA In Lung Cancer: Novel Biomarkers and Potential Tools for Treatment
Previous Article in Special Issue
Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease
Article Menu

Export Article

Open AccessFeature PaperReview
J. Clin. Med. 2016, 5(3), 37; doi:10.3390/jcm5030037

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet, Barcelona 08007, Spain
Department of Physiological Sciences II, University of Barcelona, Barcelona 08007, Spain
Author to whom correspondence should be addressed.
Academic Editor: Michael J. Edel
Received: 15 December 2015 / Revised: 1 March 2016 / Accepted: 4 March 2016 / Published: 12 March 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [1102 KB, uploaded 12 March 2016]   |  


The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but also to produce new differentiated cells. Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). However, a number of groups have recently reported that mesenchymal-epithelial transition (MET) is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. In this review, we summarize recent findings that extend our knowledge about the crossroads between EMT and stemness and their relevance under physiological or pathological conditions. View Full-Text
Keywords: EMT; MET; stem; Transforming Growth Factor-β (TGF-β); Snail; Zeb; Twist; Prrx; CD44; CD133 EMT; MET; stem; Transforming Growth Factor-β (TGF-β); Snail; Zeb; Twist; Prrx; CD44; CD133

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fabregat, I.; Malfettone, A.; Soukupova, J. New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. J. Clin. Med. 2016, 5, 37.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top