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J. Clin. Med. 2016, 5(3), 37; doi:10.3390/jcm5030037

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

1
Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet, Barcelona 08007, Spain
2
Department of Physiological Sciences II, University of Barcelona, Barcelona 08007, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Michael J. Edel
Received: 15 December 2015 / Revised: 1 March 2016 / Accepted: 4 March 2016 / Published: 12 March 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [1102 KB, uploaded 12 March 2016]   |  

Abstract

The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but also to produce new differentiated cells. Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). However, a number of groups have recently reported that mesenchymal-epithelial transition (MET) is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. In this review, we summarize recent findings that extend our knowledge about the crossroads between EMT and stemness and their relevance under physiological or pathological conditions. View Full-Text
Keywords: EMT; MET; stem; Transforming Growth Factor-β (TGF-β); Snail; Zeb; Twist; Prrx; CD44; CD133 EMT; MET; stem; Transforming Growth Factor-β (TGF-β); Snail; Zeb; Twist; Prrx; CD44; CD133
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fabregat, I.; Malfettone, A.; Soukupova, J. New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. J. Clin. Med. 2016, 5, 37.

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