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J. Clin. Med. 2015, 4(6), 1240-1268; doi:10.3390/jcm4061240

Alternative Donor Transplantation for Acute Myeloid Leukemia

1
Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 480, Minneapolis, MN 55455, USA
2
Hematology and Oncology Department, Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY 10305, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Celalettin Ustun and Lucy A. Godley
Received: 14 April 2015 / Revised: 18 May 2015 / Accepted: 21 May 2015 / Published: 9 June 2015
(This article belongs to the Special Issue AML in the Molecular Age: From Biology to Clinical Management)
View Full-Text   |   Download PDF [247 KB, uploaded 9 June 2015]

Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for adult patients with acute myeloid leukemia (AML), but its use for consolidation therapy after first remission with induction chemotherapy used to be limited to younger patients and those with suitable donors. The median age of AML diagnosis is in the late 60s. With the introduction of reduced-intensity conditioning (RIC), many older adults are now eligible to receive allo-HCT, including those who are medically less fit to receive myeloablative conditioning. Furthermore, AML patients commonly have no human leukocyte antigen (HLA)-identical or medically suitable sibling donor available to proceed with allo-HCT. Technical advances in donor matching, suppression of alloreactivity, and supportive care have made it possible to use alternative donors, such as unrelated umbilical cord blood (UCB) and partially HLA-matched related (haploidentical) donors. Outcomes after alternative donor allo-HCT are now approaching the outcomes observed for conventional allo-HCT with matched related and unrelated donors. Thus, with both UCB and haploidentical donors available, lack of donor should rarely be a limiting factor in offering an allo-HCT to adults with AML. View Full-Text
Keywords: AML; alternative donor; UCB; Haploidentical; Transplantation AML; alternative donor; UCB; Haploidentical; Transplantation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bejanyan, N.; Haddad, H.; Brunstein, C. Alternative Donor Transplantation for Acute Myeloid Leukemia. J. Clin. Med. 2015, 4, 1240-1268.

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