Open AccessThis article is
- freely available
An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 29 August 2013; in revised form: 16 September 2013 / Accepted: 21 September 2013 / Published: 1 November 2013
Abstract: With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.
Keywords: stem cells; stroke; transplantation; translational biomedical research
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Dailey, T.; Metcalf, C.; Mosley, Y.I.; Sullivan, R.; Shinozuka, K.; Tajiri, N.; Pabon, M.; Acosta, S.; Kaneko, Y.; Loveren, H.V.; Borlongan, C.V. An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside. J. Clin. Med. 2013, 2, 220-241.
Dailey T, Metcalf C, Mosley YI, Sullivan R, Shinozuka K, Tajiri N, Pabon M, Acosta S, Kaneko Y, Loveren HV, Borlongan CV. An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside. Journal of Clinical Medicine. 2013; 2(4):220-241.
Dailey, Travis; Metcalf, Christopher; Mosley, Yusef I.; Sullivan, Robert; Shinozuka, Kazutaka; Tajiri, Naoki; Pabon, Mibel; Acosta, Sandra; Kaneko, Yuji; Loveren, Harry V.; Borlongan, Cesar V. 2013. "An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside." J. Clin. Med. 2, no. 4: 220-241.