An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

doi:10.3390/jcm2040220

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J. Clin. Med. 2013, 2(4), 220-241; doi:10.3390/jcm2040220

Review

An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

Travis Dailey^†

, Christopher Metcalf^†

, Yusef I. Mosley

, Robert Sullivan

, Kazutaka Shinozuka

, Naoki Tajiri

, Mibel Pabon

, Sandra Acosta

, Yuji Kaneko

, Harry van Loveren

and Cesar V. Borlongan *

+ Authors' affiliations

Received: 29 August 2013 / Revised: 16 September 2013 / Accepted: 21 September 2013 / Published: 1 November 2013

(This article belongs to the Special Issue Frontiers in Stem Cell Treatments)

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Abstract: With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.

Keywords: stem cells; stroke; transplantation; translational biomedical research

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dailey, T.; Metcalf, C.; Mosley, Y.I.; Sullivan, R.; Shinozuka, K.; Tajiri, N.; Pabon, M.; Acosta, S.; Kaneko, Y.; Loveren, H.V.; Borlongan, C.V. An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside. J. Clin. Med. 2013, 2, 220-241.

AMA Style

Dailey T, Metcalf C, Mosley YI, Sullivan R, Shinozuka K, Tajiri N, Pabon M, Acosta S, Kaneko Y, Loveren HV, Borlongan CV. An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside. Journal of Clinical Medicine. 2013; 2(4):220-241.

Chicago/Turabian Style

Dailey, Travis; Metcalf, Christopher; Mosley, Yusef I.; Sullivan, Robert; Shinozuka, Kazutaka; Tajiri, Naoki; Pabon, Mibel; Acosta, Sandra; Kaneko, Yuji; Loveren, Harry V.; Borlongan, Cesar V. 2013. "An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside." J. Clin. Med. 2, no. 4: 220-241.

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