J. Clin. Med. 2013, 2(4), 220-241; doi:10.3390/jcm2040220
An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
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These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 29 August 2013 / Revised: 16 September 2013 / Accepted: 21 September 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Frontiers in Stem Cell Treatments)
Abstract
With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.Keywords:
stem cells; stroke; transplantation; translational biomedical research
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Dailey, T.; Metcalf, C.; Mosley, Y.I.; Sullivan, R.; Shinozuka, K.; Tajiri, N.; Pabon, M.; Acosta, S.; Kaneko, Y.; Loveren, H.V.; Borlongan, C.V. An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside. J. Clin. Med. 2013, 2, 220-241.
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