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J. Clin. Med. 2013, 2(4), 188-200; doi:10.3390/jcm2040188

Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

1
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands
2
Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 16 August 2013 / Revised: 5 September 2013 / Accepted: 11 September 2013 / Published: 16 October 2013
(This article belongs to the Special Issue Prevention and Treatment of Bone Metastases from Breast Cancer)
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Abstract

The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer.
Keywords: bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Charehbili, A.; Fontein, D.B.Y.; Kroep, J.R.; Liefers, G.-J.; Nortier, J.W.R.; Velde, C.J.H. Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy? J. Clin. Med. 2013, 2, 188-200.

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