Next Article in Journal
Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases
Next Article in Special Issue
The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment
Previous Article in Journal / Special Issue
Bone Targeted Therapies for Bone Metastasis in Breast Cancer
J. Clin. Med. 2013, 2(4), 188-200; doi:10.3390/jcm2040188
Article

Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

1,2,* , 1
,
2
,
1
,
2
 and
1
1 Department of Surgery, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands 2 Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands
* Author to whom correspondence should be addressed.
Received: 16 August 2013 / Revised: 5 September 2013 / Accepted: 11 September 2013 / Published: 16 October 2013
(This article belongs to the Special Issue Prevention and Treatment of Bone Metastases from Breast Cancer)
View Full-Text   |   Download PDF [274 KB, uploaded 16 October 2013]   |  

Abstract

The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer.
Keywords: bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Charehbili, A.; Fontein, D.B.Y.; Kroep, J.R.; Liefers, G.-J.; Nortier, J.W.R.; Velde, C.J.H. Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy? J. Clin. Med. 2013, 2, 188-200.

View more citation formats

Related Articles

Article Metrics

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert