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J. Clin. Med. 2013, 2(4), 176-187; doi:10.3390/jcm2040176
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Bone Targeted Therapies for Bone Metastasis in Breast Cancer

Received: 18 July 2013 / Revised: 7 August 2013 / Accepted: 10 September 2013 / Published: 14 October 2013
(This article belongs to the Special Issue Prevention and Treatment of Bone Metastases from Breast Cancer)
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Abstract

Cancer metastasis to the bone develops commonly in patients with various malignancies, and is a major cause of morbidity and diminished quality of life in many affected patients. Emerging treatments for metastatic bone disease have arisen from advances in our understanding of the unique cellular and molecular mechanisms that contribute to the bone metastasis. The tendency of cancer cells to metastasize to bone is probably the end result of many factors including vascular pathways, the highly vascular nature of the bone marrow (which increases the probability that cancer cells will be deposited in bone marrow capillaries), and molecular characteristics of the cancer cells that allow them to adapt to the bone marrow microenvironment. The goals of treating osseous metastases are manifold. Proper treatment can lead to significant improvements in pain control and function, and maintain skeletal integrity. The treatment plan requires a multidisciplinary approach. Widespread metastatic disease necessitates systemic therapy, while a localized problem is best managed with surgery, external beam radiotherapy, or both. Patients with bone metastasis can have prolonged survival, and proper management can have a significant impact on their quality of life. We will review the factors in this article that are promising molecular bone-targeted therapies or will be likely targets for future therapeutic intervention to restore bone remodeling and suppress tumor growth.
Keywords: bone metastasis; bisphosphonates; bone-targeted therapy; radiopharmaceuticals bone metastasis; bisphosphonates; bone-targeted therapy; radiopharmaceuticals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Razaq, W. Bone Targeted Therapies for Bone Metastasis in Breast Cancer. J. Clin. Med. 2013, 2, 176-187.

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