Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets
Department of Physics and Astronomy, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4M1, Canada
Author to whom correspondence should be addressed.
Received: 12 June 2017 / Revised: 26 July 2017 / Accepted: 23 August 2017 / Published: 31 August 2017
aggregates play a causative role in Alzheimer’s disease. These aggregates are a product of the physical environment provided by the basic neuronal membrane, composed of a lipid bilayer. The intrinsic properties of the lipid bilayer allow amyloid-
peptides to nucleate and form well-ordered cross-
sheets within the membrane. Here, we correlate the aggregation of the hydrophobic fragment of the amyloid-
, with the hydrophobicity, fluidity, and charge density of a lipid bilayer. We summarize recent biophysical studies of model membranes and relate these to the process of aggregation in physiological systems.
This is an open access article distributed under the Creative Commons Attribution License
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Khondker, A.; Alsop, R.J.; Rheinstädter, M.C. Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets. Membranes 2017, 7, 49.
Khondker A, Alsop RJ, Rheinstädter MC. Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets. Membranes. 2017; 7(3):49.
Khondker, Adree; Alsop, Richard J.; Rheinstädter, Maikel C. 2017. "Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets." Membranes 7, no. 3: 49.
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