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Membranes 2017, 7(4), 56; https://doi.org/10.3390/membranes7040056

A Comprehensive Review of Our Current Understanding of Red Blood Cell (RBC) Glycoproteins

Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Mie, Tsu 514-8507, Japan
Received: 18 August 2017 / Revised: 20 September 2017 / Accepted: 24 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Biological, Biomimetic, and Biomedical Applications of Membranes)
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Abstract

Human red blood cells (RBC), which are the cells most commonly used in the study of biological membranes, have some glycoproteins in their cell membrane. These membrane proteins are band 3 and glycophorins A–D, and some substoichiometric glycoproteins (e.g., CD44, CD47, Lu, Kell, Duffy). The oligosaccharide that band 3 contains has one N-linked oligosaccharide, and glycophorins possess mostly O-linked oligosaccharides. The end of the O-linked oligosaccharide is linked to sialic acid. In humans, this sialic acid is N-acetylneuraminic acid (NeuAc). Another sialic acid, N-glycolylneuraminic acid (NeuGc) is present in red blood cells of non-human origin. While the biological function of band 3 is well known as an anion exchanger, it has been suggested that the oligosaccharide of band 3 does not affect the anion transport function. Although band 3 has been studied in detail, the physiological functions of glycophorins remain unclear. This review mainly describes the sialo-oligosaccharide structures of band 3 and glycophorins, followed by a discussion of the physiological functions that have been reported in the literature to date. Moreover, other glycoproteins in red blood cell membranes of non-human origin are described, and the physiological function of glycophorin in carp red blood cell membranes is discussed with respect to its bacteriostatic activity. View Full-Text
Keywords: red blood cell; glycoproteins; biological function; glycophorin; band 3; O-linked oligosaccharides; N-acetylneuraminic acid; N-glycolylneuraminic acid red blood cell; glycoproteins; biological function; glycophorin; band 3; O-linked oligosaccharides; N-acetylneuraminic acid; N-glycolylneuraminic acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Aoki, T. A Comprehensive Review of Our Current Understanding of Red Blood Cell (RBC) Glycoproteins. Membranes 2017, 7, 56.

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