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Membranes 2016, 6(4), 56; doi:10.3390/membranes6040056

Vitamin E Circular Dichroism Studies: Insights into Conformational Changes Induced by the Solvent’s Polarity

1
Department of Physics, Brock University, St. Catharines, ON L2S 3A1, Canada
2
Institute of Molecular Biosciences, Biophysics Division, NAWI Graz, University of Graz, Graz 8010, Austria
3
BioTechMed-Graz, Graz 8010, Austria
4
Department of Chemistry, Brock University, St. Catharines, ON L2S 3A1, Canada
Current address: Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996, USA.
*
Authors to whom correspondence should be addressed.
Academic Editor: Shiro Suetsugu
Received: 24 October 2016 / Revised: 7 December 2016 / Accepted: 8 December 2016 / Published: 14 December 2016
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [2077 KB, uploaded 14 December 2016]   |  

Abstract

We used circular dichroism (CD) to study differences in CD spectra between α-, δ-, and methylated-α-tocopherol in solvents with different polarities. CD spectra of the different tocopherol structures differ from each other in intensity and peak locations, which can be attributed to chromanol substitution and the ability to form hydrogen bonds. In addition, each structure was examined in different polarity solvents using the Reichardt index—a measure of the solvent’s ionizing ability, and a direct measurement of solvent–solute interactions. Differences across solvents indicate that hydrogen bonding is a key contributor to CD spectra at 200 nm. These results are a first step in examining the hydrogen bonding abilities of vitamin E in a lipid bilayer. View Full-Text
Keywords: Vitamin E; α-tocopherol; δ-tocopherol; methylated tocopherol; circular dichroism; reichardt’s dye Vitamin E; α-tocopherol; δ-tocopherol; methylated tocopherol; circular dichroism; reichardt’s dye
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marquardt, D.; Van Oosten, B.J.; Ghelfi, M.; Atkinson, J.; Harroun, T.A. Vitamin E Circular Dichroism Studies: Insights into Conformational Changes Induced by the Solvent’s Polarity. Membranes 2016, 6, 56.

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