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Membranes 2014, 4(3), 525-564; doi:10.3390/membranes4030525
Review

Trafficking of ThermoTRP Channels

1
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1
,
1
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1,*  and 1,2,*
1 Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, Spain 2 BIOFISIKA, the Basque Center for Biophysics, UPV/EHU-CSIC-FBB, Bilbao 48940, Spain
* Authors to whom correspondence should be addressed.
Received: 16 June 2014 / Revised: 11 July 2014 / Accepted: 8 August 2014 / Published: 19 August 2014
(This article belongs to the Special Issue Trafficking of Membrane Receptors)
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Abstract

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential (TRP) channels that are activated by changes in the environmental temperature, from noxious cold to injurious heat. Acting as integrators of several stimuli and signalling pathways, dysfunction of these channels contributes to several pathological states. The surface expression of thermoTRPs is controlled by both, the constitutive and regulated vesicular trafficking. Modulation of receptor surface density during pathological processes is nowadays considered as an interesting therapeutic approach for management of diseases, such as chronic pain, in which an increased trafficking is associated with the pathological state. This review will focus on the recent advances trafficking of the thermoTRP channels, TRPV1, TRPV2, TRPV4, TRPM3, TRPM8 and TRPA1, into/from the plasma membrane. Particularly, regulated membrane insertion of thermoTRPs channels contributes to a fine tuning of final channel activity, and indeed, it has resulted in the development of novel therapeutic approaches with successful clinical results such as disruption of SNARE-dependent exocytosis by botulinum toxin or botulinomimetic peptides.
Keywords: TRP; thermoTRP; exocytosis; SNARE; protein-protein TRP; thermoTRP; exocytosis; SNARE; protein-protein
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ferrandiz-Huertas, C.; Mathivanan, S.; Wolf, C.J.; Devesa, I.; Ferrer-Montiel, A. Trafficking of ThermoTRP Channels. Membranes 2014, 4, 525-564.

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