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Membranes 2014, 4(3), 565-595; doi:10.3390/membranes4030565
Review

Trafficking of Kainate Receptors

1,2,3
, 1
, 1,3,4
 and 1,2,*
Received: 6 July 2014; in revised form: 4 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
(This article belongs to the Special Issue Trafficking of Membrane Receptors)
View Full-Text   |   Download PDF [998 KB, uploaded 20 August 2014]
Abstract: Ionotropic glutamate receptors (iGluRs) mediate the vast majority of excitatory neurotransmission in the central nervous system of vertebrates. In the protein family of iGluRs, kainate receptors (KARs) comprise the probably least well understood receptor class. Although KARs act as key players in the regulation of synaptic network activity, many properties and functions of these proteins remain elusive until now. Especially the precise pre-, extra-, and postsynaptic localization of KARs plays a critical role for neuronal function, as an unbalanced localization of KARs would ultimately lead to dysregulated neuronal excitability. Recently, important advances in the understanding of the regulation of surface expression, function, and agonist-dependent endocytosis of KARs have been achieved. Post-translational modifications like PKC-mediated phosphorylation and SUMOylation have been reported to critically influence surface expression and endocytosis, while newly discovered auxiliary proteins were shown to shape the functional properties of KARs.
Keywords: kainate receptor; trafficking; endocytosis; retention; assembly kainate receptor; trafficking; endocytosis; retention; assembly
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pahl, S.; Tapken, D.; Haering, S.C.; Hollmann, M. Trafficking of Kainate Receptors. Membranes 2014, 4, 565-595.

AMA Style

Pahl S, Tapken D, Haering SC, Hollmann M. Trafficking of Kainate Receptors. Membranes. 2014; 4(3):565-595.

Chicago/Turabian Style

Pahl, Steffen; Tapken, Daniel; Haering, Simon C.; Hollmann, Michael. 2014. "Trafficking of Kainate Receptors." Membranes 4, no. 3: 565-595.



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