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Vaccines 2016, 4(4), 39; doi:10.3390/vaccines4040039

Replicon RNA Viral Vectors as Vaccines

PanTherapeutics, CH 1095 Lutry, Switzerland
Academic Editor: Olga Borges
Received: 13 July 2016 / Revised: 14 October 2016 / Accepted: 28 October 2016 / Published: 7 November 2016
(This article belongs to the Special Issue Nanoparticles to Co-Deliver Immunopotentiators and Antigens)
View Full-Text   |   Download PDF [2203 KB, uploaded 7 November 2016]   |  

Abstract

Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens. Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in various animal models. Immunization of mice, chicken, pigs and primates with virus-like particles, naked RNA or layered DNA/RNA plasmids has provided protection against challenges with lethal doses of infectious agents and administered tumor cells. Both prophylactic and therapeutic efficacy has been achieved in cancer immunotherapy. Moreover, recombinant particles and replicon RNAs have been encapsulated by liposomes to improve delivery and targeting. Replicon RNA vectors have also been subjected to clinical trials. Overall, immunization with self-replicating RNA viruses provides high transient expression levels of antigens resulting in generation of neutralizing antibody responses and protection against lethal challenges under safe conditions. View Full-Text
Keywords: alphaviruses; flaviviruses; measles viruses; rhabdoviruses; antibodies; infectious diseases; tumors; disease protection alphaviruses; flaviviruses; measles viruses; rhabdoviruses; antibodies; infectious diseases; tumors; disease protection
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Lundstrom, K. Replicon RNA Viral Vectors as Vaccines. Vaccines 2016, 4, 39.

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