Vaccines 2016, 4(1), 2; https://doi.org/10.3390/vaccines4010002
Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection
1
Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
2
Department of Microbiology, School of Basic Medical Sciences, Central South University, Changsha 410078, Hunan, China
*
Author to whom correspondence should be addressed.
Academic Editor: Diane M. Harper
Received: 17 November 2015 / Revised: 31 December 2015 / Accepted: 18 January 2016 / Published: 22 January 2016
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Abstract
HIV-1 virus-like particles (VLPs) are promising vaccine candidates against HIV-1 infection. They are capable of preserving the native conformation of HIV-1 antigens and priming CD4+ and CD8+ T cell responses efficiently via cross presentation by both major histocompatibility complex (MHC) class I and II molecules. Progress has been achieved in the preclinical research of HIV-1 VLPs as prophylactic vaccines that induce broadly neutralizing antibodies and potent T cell responses. Moreover, the progress in HIV-1 dendritic cells (DC)-based immunotherapy provides us with a new vision for HIV-1 vaccine development. In this review, we describe updates from the past 5 years on the development of HIV-1 VLPs as a vaccine candidate and on the combined use of HIV particles with HIV-1 DC-based immunotherapy as efficient prophylactic and therapeutic vaccination strategies. View Full-TextKeywords:
HIV-1; virus-like paticles (VLPs); vaccine; dendritic cells-based immunotherapy; adjuvants; dendritic cells
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Zhao, C.; Ao, Z.; Yao, X. Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection. Vaccines 2016, 4, 2.
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