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Vaccines 2015, 3(4), 894-929; doi:10.3390/vaccines3040894

The Use of Synthetic Carriers in Malaria Vaccine Design

1
Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia
2
Department of Immunology and Pathology, Monash University, Melbourne, VIC 3004, Australia
3
Therapeutics and Regenerative Medicine Division, The Monash Institute of Medical Engineering (MIME), Monash University, Clayton, VIC 3800, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Vasso Apostolopoulos
Received: 12 June 2015 / Revised: 28 September 2015 / Accepted: 16 October 2015 / Published: 29 October 2015
(This article belongs to the Special Issue Vaccine Delivery)
View Full-Text   |   Download PDF [860 KB, uploaded 29 October 2015]   |  

Abstract

Malaria vaccine research has been ongoing since the 1980s with limited success. However, recent improvements in our understanding of the immune responses required to combat each stage of infection will allow for intelligent design of both antigens and their associated delivery vaccine vehicles/vectors. Synthetic carriers (also known as vectors) are usually particulate and have multiple properties, which can be varied to control how an associated vaccine interacts with the host, and consequently how the immune response develops. This review comprehensively analyzes both historical and recent studies in which synthetic carriers are used to deliver malaria vaccines. Furthermore, the requirements for a synthetic carrier, such as size, charge, and surface chemistry are reviewed in order to understand the design of effective particle-based vaccines against malaria, as well as providing general insights. Synthetic carriers have the ability to alter and direct the immune response, and a better control of particle properties will facilitate improved vaccine design in the near future. View Full-Text
Keywords: malaria; vaccine; vector; synthetic; properties; particles; nanoparticles malaria; vaccine; vector; synthetic; properties; particles; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Powles, L.; Xiang, S.D.; Selomulya, C.; Plebanski, M. The Use of Synthetic Carriers in Malaria Vaccine Design. Vaccines 2015, 3, 894-929.

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