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Vaccines 2015, 3(4), 814-828; doi:10.3390/vaccines3040814

Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform

Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA
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Author to whom correspondence should be addressed.
Academic Editor: Darrell J. Irvine
Received: 30 July 2015 / Revised: 21 September 2015 / Accepted: 22 September 2015 / Published: 6 October 2015
(This article belongs to the Special Issue Nanoparticle-Based Vaccines)
View Full-Text   |   Download PDF [336 KB, uploaded 6 October 2015]   |  

Abstract

Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation. View Full-Text
Keywords: nanomedicine; nanovaccine; biomimetic nanoparticle; membrane coating; infectious disease nanomedicine; nanovaccine; biomimetic nanoparticle; membrane coating; infectious disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Angsantikul, P.; Thamphiwatana, S.; Gao, W.; Zhang, L. Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform. Vaccines 2015, 3, 814-828.

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