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Vaccines 2015, 3(4), 803-813; doi:10.3390/vaccines3040803

Micelle-Based Adjuvants for Subunit Vaccine Delivery

1
Aix-Marseille Université, CNRS, CR UMR 7273, 13397 Marseille, France
2
Université Lyon 1, CNRS, LBTI UMR 5305, 69367 Lyon, France
*
Author to whom correspondence should be addressed.
Academic Editor: Darrell J. Irvine
Received: 29 July 2015 / Revised: 8 September 2015 / Accepted: 22 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Nanoparticle-Based Vaccines)
View Full-Text   |   Download PDF [259 KB, uploaded 13 October 2015]   |  

Abstract

In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit vaccines. Among them, self-assembled micellar nanoparticles from amphiphilic (macro)molecules have recently emerged as promising candidates. In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery. View Full-Text
Keywords: micelles; antigens; amphiphilic copolymers; peptide amphiphiles micelles; antigens; amphiphilic copolymers; peptide amphiphiles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Trimaille, T.; Verrier, B. Micelle-Based Adjuvants for Subunit Vaccine Delivery. Vaccines 2015, 3, 803-813.

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