Systems Biology Approach for Cancer Vaccine Development and Evaluation
AbstractTherapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines’ efficacy. The newly developed high throughput technologies and computational tools are instrumental to this aim allowing the identification of more specific antigens and the comprehensive analysis of the innate and adaptive immunities. Here, we review the potentiality of systems biology in providing novel insights in the mechanisms of the action of vaccines to improve their design and effectiveness. View Full-Text
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Circelli, L.; Petrizzo, A.; Tagliamonte, M.; Tornesello, M.L.; Buonaguro, F.M.; Buonaguro, L. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines 2015, 3, 544-555.
Circelli L, Petrizzo A, Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines. 2015; 3(3):544-555.Chicago/Turabian Style
Circelli, Luisa; Petrizzo, Annacarmen; Tagliamonte, Maria; Tornesello, Maria L.; Buonaguro, Franco M.; Buonaguro, Luigi. 2015. "Systems Biology Approach for Cancer Vaccine Development and Evaluation." Vaccines 3, no. 3: 544-555.