Next Article in Journal
Addressing the Vaccine Hesitancy Continuum: An Audience Segmentation Analysis of American Adults Who Did Not Receive the 2009 H1N1 Vaccine
Next Article in Special Issue
Cancer Dormancy: A Regulatory Role for Endogenous Immunity in Establishing and Maintaining the Tumor Dormant State
Previous Article in Journal / Special Issue
Anti-Tumor Effects of Peptide Therapeutic and Peptide Vaccine Antibody Co-targeting HER-1 and HER-2 in Esophageal Cancer (EC) and HER-1 and IGF-1R in Triple-Negative Breast Cancer (TNBC)
Article Menu

Export Article

Open AccessReview
Vaccines 2015, 3(3), 544-555; doi:10.3390/vaccines3030544

Systems Biology Approach for Cancer Vaccine Development and Evaluation

Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Mary Lenora (Nora) Disis
Received: 26 May 2015 / Revised: 2 July 2015 / Accepted: 3 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Cancer Vaccines)
View Full-Text   |   Download PDF [129 KB, uploaded 14 July 2015]   |  

Abstract

Therapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines’ efficacy. The newly developed high throughput technologies and computational tools are instrumental to this aim allowing the identification of more specific antigens and the comprehensive analysis of the innate and adaptive immunities. Here, we review the potentiality of systems biology in providing novel insights in the mechanisms of the action of vaccines to improve their design and effectiveness. View Full-Text
Keywords: systems vaccinology; cancer vaccine; cancer immunotherapy systems vaccinology; cancer vaccine; cancer immunotherapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Circelli, L.; Petrizzo, A.; Tagliamonte, M.; Tornesello, M.L.; Buonaguro, F.M.; Buonaguro, L. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines 2015, 3, 544-555.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top