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Vaccines 2015, 3(2), 239-262; doi:10.3390/vaccines3020239

Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head

Department of Viroscience, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
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Author to whom correspondence should be addressed.
Academic Editor: Sarah Gilbert
Received: 10 February 2015 / Revised: 11 March 2015 / Accepted: 17 March 2015 / Published: 26 March 2015
(This article belongs to the Special Issue Influenza Vaccines)
View Full-Text   |   Download PDF [430 KB, uploaded 26 March 2015]   |  

Abstract

Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes. Vaccination against influenza can be improved in two important ways, either by inducing more broadly protective immune responses or by decreasing the time of vaccine production, which is relevant especially during a pandemic outbreak. In this review, we outline the current efforts to develop so-called “universal influenza vaccines”, describing antigens that may induce broadly protective immunity and novel vaccine production platforms that facilitate timely availability of vaccines. View Full-Text
Keywords: influenza; universal vaccine; MVA influenza; universal vaccine; MVA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wiersma, L.C.M.; Rimmelzwaan, G.F.; de Vries, R.D. Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head. Vaccines 2015, 3, 239-262.

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