Vaccines 2014, 2(2), 397-421; doi:10.3390/vaccines2020397
Article

Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus

Received: 26 August 2013; in revised form: 4 April 2014 / Accepted: 16 April 2014 / Published: 27 May 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The ability to predict the conditions under which antibodies protect against viral infection would transform our approach to vaccine development. A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine. Recently, an example of antibody-mediated vaccine protection has been shown via passive transfer of neutralizing antibodies before equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Viral dynamic modeling of antibody protection from EIAV infection in SCID horses may lead to insights into the mechanisms of control of infection by antibody vaccination. In this work, such a model is constructed in conjunction with data from EIAV infection of SCID horses to gain insights into multiple strain competition in the presence of antibody control. Conditions are determined under which wild-type infection is eradicated with the antibody vaccine. In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain. The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters. This work extends the current understanding of competition and antibody control in lentiviral infection, which may provide insights into the development of vaccines that stimulate the immune system to control infection effectively.
Keywords: equine infectious anemia virus; vaccination; antibodies; mathematical modeling; lentivirus
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MDPI and ACS Style

Schwartz, E.J.; Smith?, R.J. Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus. Vaccines 2014, 2, 397-421.

AMA Style

Schwartz EJ, Smith? RJ. Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus. Vaccines. 2014; 2(2):397-421.

Chicago/Turabian Style

Schwartz, Elissa J.; Smith?, Robert J. 2014. "Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus." Vaccines 2, no. 2: 397-421.

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