Next Article in Journal
Acceptability of Condoms, Circumcision and PrEP among Young Black Men Who Have Sex with Men: A Descriptive Study Based on Effectiveness and Cost
Previous Article in Journal
Meningitis in a School-Aged Child due to Haemophilus influenzae Type E during the Post-Conjugate Vaccine Era—Monroe County, NY, 2011
Previous Article in Special Issue
Development of Streptococcus pneumoniae Vaccines Using Live Vectors
Vaccines 2014, 2(1), 112-128; doi:10.3390/vaccines2010112
Review

Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention

1,* , 2
 and
3
1 Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA 2 National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA 3 Departments of Microbiology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
* Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 18 January 2014 / Accepted: 6 February 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Pneumococcal Vaccine in the 21st Century)
View Full-Text   |   Download PDF [336 KB, uploaded 14 February 2014]
SciFeed

Abstract

Seven-valent pneumococcal conjugate vaccine (PCV7) introduction and routine pediatric use has substantially reduced the burden of Streptococcus pneumoniae disease worldwide. However, a significant amount of disease burden, due to serotypes not contained in PCV7, still exists globally. A newly recognized serotype, 6C, was until recently, identified and reported as serotype 6A. This review summarizes the serotype epidemiology of pneumococcal disease pre- and post-introduction of PCV7, available post-marketing surveillance data following the introduction of higher valency pneumococcal vaccines (PCV10, PCV13) and future prospects for the development of new pneumococcal vaccines.
Keywords: Streptococcus pneumoniae; vaccine; epidemiology; serotype; pneumococcal protein Streptococcus pneumoniae; vaccine; epidemiology; serotype; pneumococcal protein
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Lee, L.H.; Gu, X.-X.; Nahm, M.H. Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention. Vaccines 2014, 2, 112-128.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert