Vaccines 2014, 2(1), 112-128; doi:10.3390/vaccines2010112
Review

Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention

Received: 2 December 2013; in revised form: 18 January 2014 / Accepted: 6 February 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Pneumococcal Vaccine in the 21st Century)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Seven-valent pneumococcal conjugate vaccine (PCV7) introduction and routine pediatric use has substantially reduced the burden of Streptococcus pneumoniae disease worldwide. However, a significant amount of disease burden, due to serotypes not contained in PCV7, still exists globally. A newly recognized serotype, 6C, was until recently, identified and reported as serotype 6A. This review summarizes the serotype epidemiology of pneumococcal disease pre- and post-introduction of PCV7, available post-marketing surveillance data following the introduction of higher valency pneumococcal vaccines (PCV10, PCV13) and future prospects for the development of new pneumococcal vaccines.
Keywords: Streptococcus pneumoniae; vaccine; epidemiology; serotype; pneumococcal protein
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MDPI and ACS Style

Lee, L.H.; Gu, X.-X.; Nahm, M.H. Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention. Vaccines 2014, 2, 112-128.

AMA Style

Lee LH, Gu X-X, Nahm MH. Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention. Vaccines. 2014; 2(1):112-128.

Chicago/Turabian Style

Lee, Lucia H.; Gu, Xin-Xing; Nahm, Moon H. 2014. "Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention." Vaccines 2, no. 1: 112-128.

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