Vaccines 2013, 1(4), 497-512; doi:10.3390/vaccines1040497

Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens

Received: 6 September 2013; in revised form: 11 October 2013 / Accepted: 12 October 2013 / Published: 28 October 2013
(This article belongs to the Special Issue HIV Vaccines)
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Abstract: The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.
Keywords: HIV-1; vaccine; neutralizing antibodies; envelope glycoproteins; trimer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sattentau, Q.J. Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens. Vaccines 2013, 1, 497-512.

AMA Style

Sattentau QJ. Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens. Vaccines. 2013; 1(4):497-512.

Chicago/Turabian Style

Sattentau, Quentin J. 2013. "Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens." Vaccines 1, no. 4: 497-512.

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