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Antioxidants 2015, 4(3), 577-590; doi:10.3390/antiox4030577

Periodontal Disease-Induced Atherosclerosis and Oxidative Stress

1
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan
2
Stomatology Hospital, Tongji University, Shanghai 200072, China
3
Department of Periodontology, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, China
4
Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women's Medical University, Tokyo 162-8666, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 9 July 2015 / Revised: 11 August 2015 / Accepted: 18 August 2015 / Published: 2 September 2015
(This article belongs to the Special Issue Antioxidants and Periodontal Diseases)
View Full-Text   |   Download PDF [426 KB, uploaded 2 September 2015]

Abstract

Periodontal disease is a highly prevalent disorder affecting up to 80% of the global population. Recent epidemiological studies have shown an association between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. In this review, we focus on the mechanisms by which periodontopathic bacteria cause chronic inflammation through the enhancement of oxidative stress and accelerate cardiovascular disease. Furthermore, we comment on the antioxidative activity of catechin in atherosclerosis accelerated by periodontitis. View Full-Text
Keywords: inflammation; oxidative stress; systemic chronic disease; atherosclerosis; periodontal disease inflammation; oxidative stress; systemic chronic disease; atherosclerosis; periodontal disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kurita-Ochiai, T.; Jia, R.; Cai, Y.; Yamaguchi, Y.; Yamamoto, M. Periodontal Disease-Induced Atherosclerosis and Oxidative Stress. Antioxidants 2015, 4, 577-590.

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