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Antioxidants 2015, 4(3), 513-522; doi:10.3390/antiox4030513

Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study

Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 23 April 2015 / Revised: 19 June 2015 / Accepted: 1 July 2015 / Published: 9 July 2015
(This article belongs to the Special Issue Antioxidants and Periodontal Diseases)
View Full-Text   |   Download PDF [426 KB, uploaded 9 July 2015]


Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The control group (n = 6) or the HW group (n = 7). In the HW group, participants consumed HW 4–5 times/day for eight weeks. At two to four weeks, all participants received non-surgical periodontal treatment. Oral examinations were performed at baseline, two, four and eight weeks, and serum was obtained at these time points to evaluate oxidative stress. At baseline, there were no significant differences in periodontal status between the control and HW groups. The HW group showed greater improvements in probing pocket depth and clinical attachment level than the control group at two, four and eight weeks (p < 0.05). The HW group also exhibited an increased serum level of total antioxidant capacity at four weeks, compared to baseline (p < 0.05). Drinking HW enhanced the effects of non-surgical periodontal treatment, thus improving periodontitis. View Full-Text
Keywords: hydrogen; drinking water; oxidative stress; periodontitis hydrogen; drinking water; oxidative stress; periodontitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Azuma, T.; Yamane, M.; Ekuni, D.; Kawabata, Y.; Kataoka, K.; Kasuyama, K.; Maruyama, T.; Tomofuji, T.; Morita, M. Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. Antioxidants 2015, 4, 513-522.

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