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Brain Sci. 2018, 8(2), 23; https://doi.org/10.3390/brainsci8020023

The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications

1,2,3,†
,
1,2,†
,
1,2,3
,
1,2,4
and
1,2,4,*
1
Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada
2
Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
3
Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada
4
Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
Both N.B.R. and K.M. contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 December 2017 / Revised: 24 January 2018 / Accepted: 26 January 2018 / Published: 29 January 2018
View Full-Text   |   Download PDF [2016 KB, uploaded 29 January 2018]   |  

Abstract

Diffusion tensor imaging (DTI) is an MRI-based technique that delineates white matter tracts in the brain by tracking the diffusion of water in neural tissue. This methodology, known as “tractography”, has been extensively applied in clinical neuroscience to explore nervous system architecture and diseases. More recently, tractography has been used to assist with neurosurgical targeting in functional neurosurgery. This review provides an overview of DTI principles, and discusses current applications of tractography for improving and helping develop novel deep brain stimulation (DBS) targets. View Full-Text
Keywords: diffusion tensor imaging; tractography; deep brain stimulation; tremor; depression diffusion tensor imaging; tractography; deep brain stimulation; tremor; depression
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Rodrigues, N.B.; Mithani, K.; Meng, Y.; Lipsman, N.; Hamani, C. The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications. Brain Sci. 2018, 8, 23.

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