Next Article in Journal
Selective Serotonin Reuptake Inhibitors for Treating Neurocognitive and Neuropsychiatric Disorders Following Traumatic Brain Injury: An Evaluation of Current Evidence
Next Article in Special Issue
Binasal Occlusion (BNO), Visual Motion Sensitivity (VMS), and the Visually-Evoked Potential (VEP) in mild Traumatic Brain Injury and Traumatic Brain Injury (mTBI/TBI)
Previous Article in Journal
Using Machine Learning to Discover Latent Social Phenotypes in Free-Ranging Macaques
Previous Article in Special Issue
Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research
Article Menu

Export Article

Open AccessReview
Brain Sci. 2017, 7(7), 92; doi:10.3390/brainsci7070092

Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences

1
Division of Neurological Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA
2
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
*
Author to whom correspondence should be addressed.
Academic Editors: James M. Gurley and Brian D. Greenwald
Received: 25 June 2017 / Revised: 9 July 2017 / Accepted: 18 July 2017 / Published: 22 July 2017
View Full-Text   |   Download PDF [496 KB, uploaded 22 July 2017]   |  

Abstract

Mild traumatic brain injury (mTBI) is a common, although poorly-defined clinical entity. Despite its initially mild presentation, patients with mTBI can rapidly deteriorate, often due to significant expansion of intracranial hemorrhage. TBI-associated coagulopathy is the topic of significant clinical and basic science research. Unlike trauma-induced coagulopathy (TIC), TBI-associated coagulopathy does not generally follow widespread injury or global hypoperfusion, suggesting a distinct pathogenesis. Although the fundamental mechanisms of TBI-associated coagulopathy are far from clearly elucidated, several candidate molecules (tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), tissue factor (TF), and brain-derived microparticles (BDMP)) have been proposed which might explain how even minor brain injury can induce local and systemic coagulopathy. Here, we review the incidence, proposed mechanisms, and common clinical tests relevant to mTBI-associated coagulopathy and briefly summarize our own institutional experience in addition to identifying areas for further research. View Full-Text
Keywords: traumatic brain injury; concussion; coagulopathy; thromboelastography; platelet dysfunction traumatic brain injury; concussion; coagulopathy; thromboelastography; platelet dysfunction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Herbert, J.P.; Guillotte, A.R.; Hammer, R.D.; Litofsky, N.S. Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences. Brain Sci. 2017, 7, 92.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top