Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences
Abstract
:1. Introduction
2. Definition of Mild Traumatic Brain Injury
3. Coagulopathy in Traumatic Brain Injury
4. Proposed Mechanisms
5. Clinical Tests for Coagulopathy
6. Incidence
7. Consequence of Coagulopathy in Mild TBI
8. Future Directions
9. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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All TBI Patients N (%) | Isolated TBI N (%) | Non-Isolated TBI N (%) | |
---|---|---|---|
TBI patients included in analysis | 97 | 43 | 54 |
TBI patients with TEG/PM assays | 80 | 36 | 44 |
Patients with mild TBI | 54 (67.5%) | 29 (80.6%) | 25 (56.8%) |
mTBI with adenosine diphosphate (ADP) inhibition ≥60% | 17 (31.5%) | 7 (24.1%) | 10 (40.0%) |
N | Mean | Standard Deviation | 95% CI | |
---|---|---|---|---|
Control [57] | 8 | 7.4 | 8.3 | ±6.9 |
Isolated mTBI 1 | 29 | 42.3 | 27.9 | ±10.6 |
N | Prolonged PT | Prolonged PTT | Thrombocytopenic | Coagulopathic by at Least One Parameter | |
---|---|---|---|---|---|
Mild TBI | 102 | 16 (15.7%) | 4 (3.9%) | 20 (19.6%) | 33 (32.4%) |
Moderate TBI | 11 | 6 (54.5%) | 0 | 2 (18.2%) | 6 (54.5%) |
Severe TBI | 29 | 11 (37.9%) | 2 (6.9%) | 0 | 14 (48.3%) |
N | Prolonged PT | Prolonged PTT | Thrombocytopenic | |
---|---|---|---|---|
Control | 40 | 2 (5%) | 1 (2.5%) | - |
Mild TBI | 32 | 0 | 0 | 2 (6.3%) |
Moderate TBI | 3 | 1 (33.3%) | 0 | 1 (33.3%) |
Severe TBI | 4 | 0 | 0 | 0 |
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Herbert, J.P.; Guillotte, A.R.; Hammer, R.D.; Litofsky, N.S. Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences. Brain Sci. 2017, 7, 92. https://doi.org/10.3390/brainsci7070092
Herbert JP, Guillotte AR, Hammer RD, Litofsky NS. Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences. Brain Sciences. 2017; 7(7):92. https://doi.org/10.3390/brainsci7070092
Chicago/Turabian StyleHerbert, Joseph P., Andrew R. Guillotte, Richard D. Hammer, and N. Scott Litofsky. 2017. "Coagulopathy in the Setting of Mild Traumatic Brain Injury: Truths and Consequences" Brain Sciences 7, no. 7: 92. https://doi.org/10.3390/brainsci7070092