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Brain Sci. 2017, 7(7), 88; doi:10.3390/brainsci7070088

Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research

1,2
and
3,4,5,*
1
School of Nursing, Holistic Adult Health Division, University of Texas at Austin, Austin, TX 78701, USA
2
Dell Medical School, Department of Neurology, University of Texas at Austin, Austin, TX 78701, USA
3
Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15224, USA
4
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA
5
VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
*
Author to whom correspondence should be addressed.
Academic Editors: James M. Gurley and Brian D. Greenwald
Received: 27 June 2017 / Revised: 12 July 2017 / Accepted: 18 July 2017 / Published: 20 July 2017
View Full-Text   |   Download PDF [178 KB, uploaded 20 July 2017]

Abstract

Mild traumatic brain injury (mTBI) is increasingly recognized as a significant public health problem which warrants additional research. Part of the effort to understand mTBI and concussion includes modeling in animals. Controlled cortical impact (CCI) is a commonly employed and well-characterized model of experimental TBI that has been utilized for three decades. Today, several commercially available pneumatic- and electromagnetic-CCI devices exist as do a variety of standard and custom injury induction tips. One of CCI’s strengths is that it can be scaled to a number of common laboratory animals. Similarly, the CCI model can be used to produce graded TBI ranging from mild to severe. At the mild end of the injury spectrum, CCI has been applied in many ways, including to study open and closed head mTBI, repeated injuries, and the long-term deficits associated with mTBI and concussion. The purpose of this mini-review is to introduce the CCI model, discuss ways the model can be applied to study mTBI and concussion, and compare CCI to alternative pre-clinical TBI models. View Full-Text
Keywords: controlled cortical impact (CCI); traumatic brain injury (TBI); experimental TBI; concussion; mild TBI (mTBI) controlled cortical impact (CCI); traumatic brain injury (TBI); experimental TBI; concussion; mild TBI (mTBI)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Osier, N.; Dixon, C.E. Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research. Brain Sci. 2017, 7, 88.

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