Next Article in Journal
Emotion Recognition in Adolescents with Down Syndrome: A Nonverbal Approach
Next Article in Special Issue
Postnatal Migration of Cerebellar Interneurons
Previous Article in Journal / Special Issue
Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex
Article Menu

Export Article

Open AccessReview
Brain Sci. 2017, 7(5), 54; doi:10.3390/brainsci7050054

Neuronal Migration and AUTS2 Syndrome

Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo 187-8502, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kazuhito Toyooka
Received: 19 April 2017 / Revised: 8 May 2017 / Accepted: 11 May 2017 / Published: 14 May 2017
(This article belongs to the Special Issue Neuronal Migration and Cortical Development)
View Full-Text   |   Download PDF [956 KB, uploaded 14 May 2017]   |  

Abstract

Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migration causes mental dysfunction. Recently, a key gene for various psychiatric diseases, the Autism susceptibility candidate 2 (AUTS2), has been shown to regulate neuronal migration, which gives new insight into understanding this question. Interestingly, the AUTS2 protein has dual functions: Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). In this review, we discuss AUTS2 from the viewpoint of human genetics, molecular function, brain development, and behavior in animal models, focusing on its role in neuronal migration. View Full-Text
Keywords: Autism; intellectual disabilities; AUTS2 syndrome; Rac1; neuritogenesis; neuronal migration; cytoskeleton; PRC1 Autism; intellectual disabilities; AUTS2 syndrome; Rac1; neuritogenesis; neuronal migration; cytoskeleton; PRC1
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hori, K.; Hoshino, M. Neuronal Migration and AUTS2 Syndrome. Brain Sci. 2017, 7, 54.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top