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Brain Sci. 2017, 7(5), 53; doi:10.3390/brainsci7050053

Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex

1
Department of Environment and Health, Vrije Universiteit Amsterdam, De Boelelaan 1087, Amsterdam 1081 HV, The Netherlands
2
Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam 1105 BA, The Netherlands
3
Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, Leiden 2300 RC, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Kazuhito Toyooka
Received: 9 March 2017 / Revised: 21 April 2017 / Accepted: 2 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Neuronal Migration and Cortical Development)
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Abstract

The migration of neuronal cells in the developing cerebral cortex is essential for proper development of the brain and brain networks. Disturbances in this process, due to genetic abnormalities or exogenous factors, leads to aberrant brain formation, brain network formation, and brain function. In the last decade, there has been extensive research in the field of neuronal migration. In this review, we describe different methods and approaches to assess and study neuronal migration in the developing cerebral cortex. First, we discuss several genetic methods, techniques and genetic models that have been used to study neuronal migration in the developing cortex. Second, we describe several molecular approaches to study aberrant neuronal migration in the cortex which can be used to elucidate the underlying mechanisms of neuronal migration. Finally, we describe model systems to investigate and assess the potential toxicity effect of prenatal exposure to environmental chemicals on proper brain formation and neuronal migration. View Full-Text
Keywords: cortex; migration; neuron; progenitor; knockout; genetic; molecular cortex; migration; neuron; progenitor; knockout; genetic; molecular
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dudok, J.J.; Leonards, P.E.G.; Wijnholds, J. Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex. Brain Sci. 2017, 7, 53.

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