Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex
AbstractThe migration of neuronal cells in the developing cerebral cortex is essential for proper development of the brain and brain networks. Disturbances in this process, due to genetic abnormalities or exogenous factors, leads to aberrant brain formation, brain network formation, and brain function. In the last decade, there has been extensive research in the field of neuronal migration. In this review, we describe different methods and approaches to assess and study neuronal migration in the developing cerebral cortex. First, we discuss several genetic methods, techniques and genetic models that have been used to study neuronal migration in the developing cortex. Second, we describe several molecular approaches to study aberrant neuronal migration in the cortex which can be used to elucidate the underlying mechanisms of neuronal migration. Finally, we describe model systems to investigate and assess the potential toxicity effect of prenatal exposure to environmental chemicals on proper brain formation and neuronal migration. View Full-Text
Share & Cite This Article
Dudok, J.J.; Leonards, P.E.G.; Wijnholds, J. Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex. Brain Sci. 2017, 7, 53.
Dudok JJ, Leonards PEG, Wijnholds J. Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex. Brain Sciences. 2017; 7(5):53.Chicago/Turabian Style
Dudok, Jacobus J.; Leonards, Pim E.G.; Wijnholds, Jan. 2017. "Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex." Brain Sci. 7, no. 5: 53.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.