Next Article in Journal
Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis
Previous Article in Journal
Promoting Mental Health in Unaccompanied Refugee Minors: Recommendations for Primary Support Programs
Previous Article in Special Issue
Immunotherapy for Pediatric Brain Tumors
Article Menu

Export Article

Open AccessCommunication
Brain Sci. 2017, 7(11), 147; doi:10.3390/brainsci7110147

4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma

1
Sanford Children’s Health Research Center, Department of Pediatrics, Cancer Biology and Immunotherapies, Sanford Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
2
Biomedical Engineering Department, University of South Dakota, Vermillion, SD 57069, USA
3
4SC AG, Fraunhoferstraße 22, 82152 Planegg, Germany
4
Immunic AG, Am Klopferspitz 19, 82152 Planegg, Germany
*
Author to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 20 October 2017 / Accepted: 23 October 2017 / Published: 3 November 2017
(This article belongs to the Special Issue Advances in Adult and Pediatric Brain Tumor Management)
View Full-Text   |   Download PDF [2515 KB, uploaded 3 November 2017]   |  

Abstract

This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7). View Full-Text
Keywords: 4SC-202; medulloblastoma; pediatric brain tumor; microarray; bioinformatics 4SC-202; medulloblastoma; pediatric brain tumor; microarray; bioinformatics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Messerli, S.M.; Hoffman, M.M.; Gnimpieba, E.Z.; Kohlhof, H.; Bhardwaj, R.D. 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sci. 2017, 7, 147.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top