4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma
AbstractThis project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7). View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Messerli, S.M.; Hoffman, M.M.; Gnimpieba, E.Z.; Kohlhof, H.; Bhardwaj, R.D. 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sci. 2017, 7, 147.
Messerli SM, Hoffman MM, Gnimpieba EZ, Kohlhof H, Bhardwaj RD. 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sciences. 2017; 7(11):147.Chicago/Turabian Style
Messerli, Shanta M.; Hoffman, Mariah M.; Gnimpieba, Etienne Z.; Kohlhof, Hella; Bhardwaj, Ratan D. 2017. "4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma." Brain Sci. 7, no. 11: 147.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.