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Brain Sci. 2017, 7(10), 137; doi:10.3390/brainsci7100137

Immunotherapy for Pediatric Brain Tumors

University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lilian S. Wells Department of Neurosurgery, 1149 South Newell Drive, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
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Received: 16 August 2017 / Revised: 20 September 2017 / Accepted: 18 October 2017 / Published: 21 October 2017
(This article belongs to the Special Issue Advances in Adult and Pediatric Brain Tumor Management)
View Full-Text   |   Download PDF [211 KB, uploaded 21 October 2017]

Abstract

Malignant brain tumors are the most common cause of solid cancer death in children. New targeted therapies are vital to improve treatment outcomes, but must be developed to enable trafficking across the blood brain barrier (BBB). Since activated T cells cross the BBB, cancer immunotherapy can be harnessed to unlock the cytotoxic potential of the immune system. However, standard of care treatments (i.e., chemotherapy and radiation) applied concomitant to pediatric brain tumor immunotherapy may abrogate induction of immunotherapeutic responses. This review will discuss the development of immunotherapies within this paradigm using emerging approaches being investigated in phase I/II trials in children with refractory brain tumors, including checkpoint inhibitors, vaccine immunotherapy, and adoptive cell therapy. View Full-Text
Keywords: immunotherapy; pediatric brain tumors; vaccines immunotherapy; pediatric brain tumors; vaccines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sayour, E.J.; Mitchell, D.A. Immunotherapy for Pediatric Brain Tumors. Brain Sci. 2017, 7, 137.

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