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Brain Sci. 2017, 7(11), 148; doi:10.3390/brainsci7110148

Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany
Received: 31 August 2017 / Revised: 31 October 2017 / Accepted: 2 November 2017 / Published: 7 November 2017
(This article belongs to the Special Issue Pathophysiology and Imaging Diagnosis of Demyelinating Disorders)
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Abstract

Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis. Multiple sclerosis is the most common inflammatory disorder of the central nervous system, characterized by focal immune cell infiltration, activation of microglia and astrocytes, along with progressive damage to myelin sheaths, axons, and neurons. The current review begins with the identification of memory cell types in the previous literature and a recent description of the modulation of these cell types in T, B, and resident memory cells in the presence of different clinically approved multiple sclerosis drugs. Overall, this review paper tries to determine the potential of memory cells to act as a target for the current or newly-developed drugs. View Full-Text
Keywords: multiple sclerosis; MS; central memory T cells; TCM; effector memory T cells; TEM; resident memory T cells; TRM multiple sclerosis; MS; central memory T cells; TCM; effector memory T cells; TEM; resident memory T cells; TRM
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bose, T. Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis. Brain Sci. 2017, 7, 148.

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