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Brain Sci. 2017, 7(10), 129; doi:10.3390/brainsci7100129

Neural Hyperexcitability in Autism Spectrum Disorders

1
Department of Psychiatry, University of Texas Southwestern, Dallas, TX 75390, USA
2
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45220, USA
*
Author to whom correspondence should be addressed.
Received: 5 September 2017 / Revised: 29 September 2017 / Accepted: 5 October 2017 / Published: 13 October 2017
(This article belongs to the Special Issue Autism Spectrum Disorder: From Etio-Pathology to Treatment)
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Abstract

Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed. View Full-Text
Keywords: autism; sensory abnormalities; inhibition; individual differences; sensory hypersensitivity; sensory hyposensitivity autism; sensory abnormalities; inhibition; individual differences; sensory hypersensitivity; sensory hyposensitivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takarae, Y.; Sweeney, J. Neural Hyperexcitability in Autism Spectrum Disorders. Brain Sci. 2017, 7, 129.

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