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Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role?
Sleep and Development Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
Institute of Pharmacology and Toxicology, Section of Chronobiology and Sleep Research, University of Zurich, 8057 Zurich, Switzerland
Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
Neuroscience Center Zurich, ETH and University of Zurich, 8057 Zurich, Switzerland
* Author to whom correspondence should be addressed.
Received: 4 September 2013; in revised form: 21 October 2013 / Accepted: 29 October 2013 / Published: 12 November 2013
Abstract: Sleep has beneficial effects on brain function and learning, which are reflected in plastic changes in the cortex. Early childhood is a time of rapid maturation in fundamental skills—e.g., language, cognitive control, working memory—that are predictive of future functioning. Little is currently known about the interactions between sleep and brain maturation during this developmental period. We propose coherent electroencephalogram (EEG) activity during sleep may provide unique insight into maturational processes of functional brain connectivity. Longitudinal sleep EEG assessments were performed in eight healthy subjects at ages 2, 3 and 5 years. Sleep EEG coherence increased across development in a region- and frequency-specific manner. Moreover, although connectivity primarily decreased intra-hemispherically across a night of sleep, an inter-hemispheric overnight increase occurred in the frequency range of slow waves (0.8–2 Hz), theta (4.8–7.8 Hz) and sleep spindles (10–14 Hz), with connectivity changes of up to 20% across a night of sleep. These findings indicate sleep EEG coherence reflects processes of brain maturation—i.e., programmed unfolding of neuronal networks—and moreover, sleep-related alterations of brain connectivity during the sensitive maturational window of early childhood.
Keywords: sleep EEG; coherence; development; maturation; children; early childhood
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Kurth, S.; Achermann, P.; Rusterholz, T.; LeBourgeois, M.K. Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role? Brain Sci. 2013, 3, 1445-1460.
Kurth S, Achermann P, Rusterholz T, LeBourgeois MK. Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role? Brain Sciences. 2013; 3(4):1445-1460.
Kurth, Salome; Achermann, Peter; Rusterholz, Thomas; LeBourgeois, Monique K. 2013. "Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role?" Brain Sci. 3, no. 4: 1445-1460.