Altered Intrinsic Functional Connectivity in Language-Related Brain Regions in Association with Verbal Memory Performance in Euthymic Bipolar Patients
Abstract
:1. Introduction
2. Results and Discussion
2.1. Cognitive Testing and Individual Psychopathology
2.2. Seed Region: HG Bilateral
PAT Mean (SD) | CON Mean (SD) | Significance | |
---|---|---|---|
Number | 21 | 20 | - |
Gender | 9 f/12 m | 8 f/12 m | χ2 = 0.03, p = 0.55 |
Age (years) | 35.67 (10.68) | 36.90 (11.06) | t = 0.36, p = 0.72 |
MWT-B | 29.86 (3.31) | 31.80 (2.98) | z = −1.83, p = 0.06 |
Handedness | all right handed | all right handed | - |
BDI | 9.85 (9.00) | 2.00 (3.57) | t = 3.64, p = 0.001 |
BRMAS | 0.38 (0.59) | 0.25 (0.44) | t = 0.80, p = 0.43 |
PANAS PA | 25.62 (8.34) | 35.75 (4.61) | t = −4.84, p < 0.01 |
PANAS NA | 15.71 (5.25) | 14.20 (4.01) | t = 1.03, p = 0.31 |
CVLT LS | 53.90 (10.27) | 61.45 (7.21) | t = −2.73, p = 0.01 |
CVLT DFR I | 11.29 (2.76) | 13.55 (1.88) | t = −3.06, p =0.004 |
CVLT DFR II | 12.33 (3.02) | 14.05 (1.70) | t = −2.26, p = 0.031 |
CVLT YNR | 15.10 (1.14) | 15.60 (0.68) | t = −1.74, p = 0.092 |
2.3. Seed Region: PT Bilateral
Seed-Region | Area | BA | TAL-Coordinates | Nr of voxels | group | FC | T | P |
---|---|---|---|---|---|---|---|---|
bilateral HG | center middle temporal gyrus | 22 | −58, −36, 5 | 929 | CON | 0.12 (0.09) | 3.94 | <0.01 |
PAT | 0.02 (0.07) | |||||||
bilateral PT | right middle & superior temporal gyrus | 22 | 51, −35, 4 | 949 | CON | 0.23 (0.07) | 4.35 | <0.01 |
PAT | 0.14 (0.06) | |||||||
right inferior frontal gyrus, precentral gyrus, insula | 13, 44 | 45, 7, 11 | 1406 | CON | 0.05 (0.06) | −3,20 | <0.01 | |
PAT | 0.13 (0.10) |
2.4. Correlation Analysis
2.4.1. Individual Psychopathology
2.4.2. Cognitive Performance
Seed-Region | Area | group | Significant correlations |
---|---|---|---|
bilateral HG | center middle temporal gyrus | CON | - |
PAT | - | ||
bilateral PT | right middle & superior temporal gyrus | CON | - |
PAT | CVLT LS: r = −0.477, p = 0.029 | ||
right inferior frontal gyrus, precentral gyrus, insula | CON | CVLT YNR: r = −0.479, p = 0.033 | |
PAT | - |
2.4.3. Medication
2.5. Summary of Results
2.6. Association with Language-Related Memory Performance
2.7. Association with Individual Psychopathology
2.8. Limitations
3. Experimental Section
3.1. Participants
3.2. Cognitive Testing
3.3. Individual Psychopathology
3.4. Imaging: Data Acquisition
3.5. Imaging: Data Preprocessing
3.6. Imaging: Statistical Analysis
3.7. Correlation Analyses
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Reinke, B.; Ven, V.V.d.; Matura, S.; Linden, D.E.J.; Oertel-Knöchel, V. Altered Intrinsic Functional Connectivity in Language-Related Brain Regions in Association with Verbal Memory Performance in Euthymic Bipolar Patients. Brain Sci. 2013, 3, 1357-1373. https://doi.org/10.3390/brainsci3031357
Reinke B, Ven VVd, Matura S, Linden DEJ, Oertel-Knöchel V. Altered Intrinsic Functional Connectivity in Language-Related Brain Regions in Association with Verbal Memory Performance in Euthymic Bipolar Patients. Brain Sciences. 2013; 3(3):1357-1373. https://doi.org/10.3390/brainsci3031357
Chicago/Turabian StyleReinke, Britta, Vincent Van de Ven, Silke Matura, David E. J. Linden, and Viola Oertel-Knöchel. 2013. "Altered Intrinsic Functional Connectivity in Language-Related Brain Regions in Association with Verbal Memory Performance in Euthymic Bipolar Patients" Brain Sciences 3, no. 3: 1357-1373. https://doi.org/10.3390/brainsci3031357