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Brain Sci. 2013, 3(4), 1597-1614; doi:10.3390/brainsci3041597
Article

Reorganization and Stability for Motor and Language Areas Using Cortical Stimulation: Case Example and Review of the Literature

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Received: 16 October 2013; Accepted: 14 November 2013 / Published: 26 November 2013
(This article belongs to the Special Issue Brain and Language)
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Abstract: The cerebral organization of language in epilepsy patients has been studied with invasive procedures such as Wada testing and electrical cortical stimulation mapping and more recently with noninvasive neuroimaging techniques, such as functional MRI. In the setting of a chronic seizure disorder, clinical variables have been shown to contribute to cerebral language reorganization underscoring the need for language lateralization and localization procedures. We present a 14-year-old pediatric patient with a refractory epilepsy disorder who underwent two neurosurgical resections of a left frontal epileptic focus separated by a year. He was mapped extraoperatively through a subdural grid using cortical stimulation to preserve motor and language functions. The clinical history and extensive workup prior to surgery is discussed as well as the opportunity to compare the cortical maps for language, motor, and sensory function before each resection. Reorganization in cortical tongue sensory areas was seen concomitant with a new zone of ictal and interictal activity in the previous tongue sensory area. Detailed neuropsychological data is presented before and after any surgical intervention to hypothesize about the extent of reorganization between epochs. We conclude that intrahemispheric cortical plasticity does occur following frontal lobe resective surgery in a teenager with medically refractory seizures.
Keywords: language; motor; cortical stimulation; reorganization; pediatric language; motor; cortical stimulation; reorganization; pediatric
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Serafini, S.; Komisarow, J.M.; Gallentine, W.; Mikati, M.A.; Bonner, M.J.; Kranz, P.G.; Haglund, M.M.; Grant, G. Reorganization and Stability for Motor and Language Areas Using Cortical Stimulation: Case Example and Review of the Literature. Brain Sci. 2013, 3, 1597-1614.

AMA Style

Serafini S, Komisarow JM, Gallentine W, Mikati MA, Bonner MJ, Kranz PG, Haglund MM, Grant G. Reorganization and Stability for Motor and Language Areas Using Cortical Stimulation: Case Example and Review of the Literature. Brain Sciences. 2013; 3(4):1597-1614.

Chicago/Turabian Style

Serafini, Sandra; Komisarow, Jordan M.; Gallentine, William; Mikati, Mohamad A.; Bonner, Melanie J.; Kranz, Peter G.; Haglund, Michael M.; Grant, Gerald. 2013. "Reorganization and Stability for Motor and Language Areas Using Cortical Stimulation: Case Example and Review of the Literature." Brain Sci. 3, no. 4: 1597-1614.


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