Next Article in Journal
Anterior Prefrontal Contributions to Implicit Attention Control
Next Article in Special Issue
The Hepatocyte Growth Factor/c-Met Antagonist, Divalinal-Angiotensin IV, Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats
Previous Article in Journal
Behavior in Oblivion: The Neurobiology of Subliminal Priming
Article Menu

Export Article

Open AccessArticle
Brain Sci. 2012, 2(2), 242-253; doi:10.3390/brainsci2020242

A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens

1
Laboratory of Behavioral Physiology, School of Medicine, University of Los Andes, Mérida 5101-A, Venezuela
2
Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
3
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA
4
Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, NY 10065, USA
Deceased in June 2011.
*
Author to whom correspondence should be addressed.
Received: 10 April 2012 / Revised: 4 May 2012 / Accepted: 1 June 2012 / Published: 11 June 2012
(This article belongs to the Special Issue Addiction and Neuroadaptation)
View Full-Text   |   Download PDF [389 KB, uploaded 11 June 2012]   |  

Abstract

Evidence links dopamine (DA) in the nucleus accumbens (NAc) shell to the ingestion of palatable diets. Less is known, however, about the specific relation of DA to dietary fat and circulating triglycerides (TG), which are stimulated by fat intake and promote overeating. The present experiments tested in Sprague-Dawley rats whether extracellular levels of NAc DA increase in response to acute access to fat-rich food or peripheral injection of a fat emulsion and, if so, whether this is related to caloric intake or elevated circulating lipids. When rats consumed more calories of a high-fat meal compared with a low-fat meal, there was a significant increase in extracellular accumbens DA (155% vs. 119%). Systemic injection of a fat emulsion, which like a high-fat diet raises circulating TG but eliminates the factor of taste and allows for the control of caloric intake, also significantly increased extracellular levels of DA (127%) compared to an equicaloric glucose solution (70%) and saline (85%). Together, this suggests that a rise in circulating TG may contribute to the stimulatory effect of a high-fat diet on NAc DA.
Keywords: dopamine; nucleus accumbens; triglycerides; high-fat; microdialysis; rat dopamine; nucleus accumbens; triglycerides; high-fat; microdialysis; rat
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rada, P.; Avena, N.M.; Barson, J.R.; Hoebel, B.G.; Leibowitz, S.F. A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens. Brain Sci. 2012, 2, 242-253.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top