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Brain Sciences, Volume 10, Issue 6

2020 June - 86 articles

Cover Story: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is considered to be the leading nontraumatic cause of neurological disability in young adults. The Holy Grail for the treatment of MS is to specifically suppress the disease while at the same time allow the immune system to be active against infections and malignancy. This could be achieved by developing immunotherapies designed to specifically suppress immune responses to myelin antigens. This study aims to review different myelin antigen-specific strategies for the prevention/treatment of MS and the challenges they face in being translated to MS patients. View this paper
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Articles (86)

  • Article
  • Open Access
18 Citations
4,166 Views
27 Pages

Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective

  • C. Leonardo Jimenez Chavez,
  • Michal A. Coelho,
  • Lindsey W. Brewin,
  • Isaiah Swauncy,
  • Tori Tran,
  • Taylor Albanese,
  • Angie Laguna,
  • Ivette Gabriela and
  • Karen K. Szumlinski

A prior history of excessive drinking induces a negative affective state in both humans and laboratory rodents, the manifestation of which varies with the age of drinking-onset. In adolescent male mice, negative affect incubates over the course of a...

(This article belongs to the Special Issue Molecular and Cellular Mechanisms Mediating the Behavioral Effects of Alcohol)
  • Article
  • Open Access
23 Citations
4,263 Views
26 Pages

Deafness in both ears is highly disruptive to communication in everyday listening situations. Many individuals with profound deafness receive bilateral cochlear implants (CIs) to gain access to spatial cues used in localization and speech understandi...

(This article belongs to the Special Issue Central Auditory Plasticity)
  • Article
  • Open Access
14 Citations
5,099 Views
23 Pages

Neurodynamics of Patients during a Dolphin-Assisted Therapy by Means of a Fractal Intraneural Analysis

  • Oswaldo Morales Matamoros,
  • Jesús Jaime Moreno Escobar,
  • Ricardo Tejeida Padilla and
  • Ixchel Lina Reyes

The recent proliferation of sensor technology applications in therapies for children’s disabilities to promote positive behavior among such children has produced optimistic results in developing a variety of skills and abilities in them. Dolphi...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
17 Citations
7,855 Views
20 Pages

Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potent...

  • Article
  • Open Access
25 Citations
4,586 Views
12 Pages

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

  • Martin Klietz,
  • Theresa Schnur,
  • Simon C. Drexel,
  • Florian Lange,
  • Lejla Paracka,
  • Meret K. Huber,
  • Dirk Dressler,
  • Günter U. Höglinger and
  • Florian Wegner

Parkinson’s disease (PD) is the second most frequent neurodegenerative disease of people who are beyond 50 years of age. People with PD (PwP) suffer from a large variety of motor and non-motor symptoms resulting in reduced health-related qualit...

  • Brief Report
  • Open Access
18 Citations
5,193 Views
11 Pages

Increased Neural Reward Responsivity in Adolescents with ASD after Social Skills Intervention

  • Elizabeth Baker,
  • Elina Veytsman,
  • Ann Marie Martin,
  • Jan Blacher and
  • Katherine K. M. Stavropoulos

The reward system has been implicated as a potential neural mechanism underlying social-communication deficits in individuals with autism spectrum disorder (ASD). However, it remains unclear whether the neural reward system in ASD is sensitive to beh...

(This article belongs to the Special Issue Advances in Autism Research)
  • Article
  • Open Access
35 Citations
7,541 Views
14 Pages

Amplified Concern for Social Risk in Adolescence: Development and Validation of a New Measure

  • Jack L. Andrews,
  • Lucy E. Foulkes,
  • Jessica K. Bone and
  • Sarah-Jayne Blakemore

In adolescence, there is a heightened propensity to take health risks such as smoking, drinking or driving too fast. Another facet of risk taking, social risk, has largely been neglected. A social risk can be defined as any decision or action that co...

  • Article
  • Open Access
17 Citations
19,598 Views
11 Pages

Human Figure Drawings in Children with Autism Spectrum Disorders: A Possible Window on the Inner or the Outer World

  • Pamela Papangelo,
  • Martina Pinzino,
  • Susanna Pelagatti,
  • Maddalena Fabbri-Destro and
  • Antonio Narzisi

Background: Tests based on human figure drawings (HFD) have captured the attention of clinicians and psychologists for a long time. The aim of the present study was to evaluate the performance of HFD of children with autism spectrum disorders (ASDs)...

(This article belongs to the Special Issue Advances in Autism Research)
  • Case Report
  • Open Access
11 Citations
5,020 Views
12 Pages

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies

  • Dominique Endres,
  • Harald Prüss,
  • Michel Rijntjes,
  • Tina Schweizer,
  • Rita Werden,
  • Kathrin Nickel,
  • Sophie Meixensberger,
  • Kimon Runge,
  • Horst Urbach and
  • Ludger Tebartz van Elst
  • + 2 authors

Background: Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the contex...

(This article belongs to the Special Issue Cerebrospinal Fluid Biomarkers in Dementia Disorders)
  • Article
  • Open Access
19 Citations
4,823 Views
11 Pages

Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency

  • Anna Grzywacz,
  • Wojciech Barczak,
  • Jolanta Chmielowiec,
  • Krzysztof Chmielowiec,
  • Aleksandra Suchanecka,
  • Grzegorz Trybek,
  • Jolanta Masiak,
  • Paweł Jagielski,
  • Katarzyna Grocholewicz and
  • Blazej Rubiś

The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, as well as epigenetic factors. Many studies have attempted to discover a molecular basis for this disease. However, our study aimed at e...

(This article belongs to the Special Issue The Role of Dopamine in Neural Circuits)
  • Review
  • Open Access
90 Citations
23,505 Views
12 Pages

Theory of Mind (ToM) is a multifaceted skill set which encompasses a variety of cognitive and neurobiological aspects. ToM deficits have long been regarded as one of the most disabling features in individuals with Autism Spectrum Disorder. One of the...

(This article belongs to the Special Issue Advances in Autism Research)
  • Article
  • Open Access
9 Citations
4,738 Views
17 Pages

Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri

  • Paolo de Girolamo,
  • Adele Leggieri,
  • Antonio Palladino,
  • Carla Lucini,
  • Chiara Attanasio and
  • Livia D’Angelo

Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons. The age-dependent regulation of NTRK1/NTRKA and p75/NGFR in mammalian brain results in...

(This article belongs to the Section Developmental Neuroscience)
  • Article
  • Open Access
15 Citations
5,942 Views
11 Pages

Neurochemical Correlates of Brain Atrophy in Fibromyalgia Syndrome: A Magnetic Resonance Spectroscopy and Cortical Thickness Study

  • Paola Feraco,
  • Salvatore Nigro,
  • Luca Passamonti,
  • Alessandro Grecucci,
  • Maria Eugenia Caligiuri,
  • Cesare Gagliardo and
  • Antonella Bacci

(1) Background: Recently, a series of clinical neuroimaging studies on fibromyalgia (FM) have shown a reduction in cortical volume and abnormally high glutamate (Glu) and glutamate + glutamine (Glx) levels in regions associated with pain modulation....

(This article belongs to the Special Issue Collection on Clinical Neuroscience)
  • Review
  • Open Access
9 Citations
10,294 Views
28 Pages

Biological and artificial intelligence (AI) are often defined by their capacity to achieve a hierarchy of short-term and long-term goals that require incorporating information over time and space at both local and global scales. More advanced forms o...

  • Article
  • Open Access
24 Citations
5,124 Views
15 Pages

The effect of the predominant playing position of elite basketball players on executive functions using both behavioral and electrophysiological measurements was investigated in the present study. Forty-six elite basketball players, including 27 guar...

(This article belongs to the Special Issue Studying Brain Activity in Sports Performance)
  • Article
  • Open Access
36 Citations
6,327 Views
17 Pages

The aim of this study was to examine the effect of mental fatigue on postural sway under different sensory conditions in healthy older adults and in persons with chronic stroke (PwCS). Thirty healthy older adults (> 60 years old), randomly separat...

(This article belongs to the Special Issue Balance Rehabilitation in Neurological Disorders)
  • Review
  • Open Access
27 Citations
5,740 Views
15 Pages

Functional Aspects of Hypothalamic Asymmetry

  • David Sandor Kiss,
  • Istvan Toth,
  • Gergely Jocsak,
  • Zoltan Barany,
  • Tibor Bartha,
  • Laszlo V. Frenyo,
  • Tamas L. Horvath and
  • Attila Zsarnovszky

Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with ph...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
9 Citations
5,796 Views
12 Pages

Lacking Pace but Not Precision: Age-Related Information Processing Changes in Response to a Dynamic Attentional Control Task

  • Anna Torrens-Burton,
  • Claire J. Hanley,
  • Rodger Wood,
  • Nasreen Basoudan,
  • Jade Eloise Norris,
  • Emma Richards and
  • Andrea Tales

Age-related decline in information processing can have a substantial impact on activities such as driving. However, the assessment of these changes is often carried out using cognitive tasks that do not adequately represent the dynamic process of upd...

(This article belongs to the Special Issue Visual Attention-Related Processing: Perspectives from Ageing, Cognitive Decline and Dementia)
  • Article
  • Open Access
18 Citations
7,188 Views
18 Pages

(1) Background: Reward responsiveness (RR) is a risk factor for high-risk behaviors such as aggressive behaviors and early sexual initiation, which are all reported to be higher in African American and low socioeconomic status adolescents. At the sam...

(This article belongs to the Special Issue Connections between Parental Involvement and Treatment of Children with Autism Spectrum Disorders (ASD))
  • Feature Paper
  • Article
  • Open Access
31 Citations
7,393 Views
29 Pages

A Novel Connectome-based Electrophysiological Study of Subjective Cognitive Decline Related to Alzheimer’s Disease by Using Resting-state High-density EEG EGI GES 300

  • Ioulietta Lazarou,
  • Kostas Georgiadis,
  • Spiros Nikolopoulos,
  • Vangelis P. Oikonomou,
  • Anthoula Tsolaki,
  • Ioannis Kompatsiaris,
  • Magda Tsolaki and
  • Dimitris Kugiumtzis

Aim: To investigate for the first time the brain network in the Alzheimer’s disease (AD) spectrum by implementing a high-density electroencephalography (HD-EEG - EGI GES 300) study with 256 channels in order to seek if the brain connectome can...

(This article belongs to the Special Issue Human Brain Dynamics: Latest Advances and Prospects)
  • Case Report
  • Open Access
6 Citations
5,383 Views
12 Pages

Microstructural Changes in Motor Functional Conversion Disorder: Multimodal Imaging Approach on a Case

  • Mariachiara Longarzo,
  • Carlo Cavaliere,
  • Giulia Mele,
  • Stefano Tozza,
  • Liberatore Tramontano,
  • Vincenzo Alfano,
  • Marco Aiello,
  • Marco Salvatore and
  • Dario Grossi

Background: Functional motor conversion disorders are characterized by neurological symptoms unrelated to brain structural lesions. The present study was conducted on a woman presenting motor symptoms causing motor dysfunction, using advanced multimo...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Feature Paper
  • Review
  • Open Access
100 Citations
15,373 Views
13 Pages

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

  • Olalla Sáiz-Vazquez,
  • Alicia Puente-Martínez,
  • Silvia Ubillos-Landa,
  • Joaquín Pacheco-Bonrostro and
  • Javier Santabárbara

Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promi...

(This article belongs to the Section Neurodegenerative Diseases)
  • Review
  • Open Access
37 Citations
8,212 Views
18 Pages

Importance of the Role of ω-3 and ω-6 Polyunsaturated Fatty Acids in the Progression of Brain Cancer

  • Mayra Montecillo-Aguado,
  • Belen Tirado-Rodriguez,
  • Zhen Tong,
  • Owen M. Vega,
  • Mario Morales-Martínez,
  • Shaheen Abkenari,
  • José Pedraza-Chaverri and
  • Sara Huerta-Yepez

Brain cancer is one of the most malignant types of cancer in both children and adults. Brain cancer patients tend to have a poor prognosis and a high rate of mortality. Additionally, 20–40% of all other types of cancer can develop brain metasta...

(This article belongs to the Section Environmental Neuroscience)
  • Article
  • Open Access
5 Citations
3,994 Views
14 Pages

In this study, we aimed to evaluate the process applied in subjects with Autism Spectrum Disorder (ASD) to elaborate and communicate their experiences of daily life activities, as well as to assess the autonomic nervous system response that subtend s...

(This article belongs to the Special Issue Advances in Autism Research)
  • Article
  • Open Access
13 Citations
5,332 Views
15 Pages

Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience

  • Marco Luigetti,
  • Angela Romano,
  • Andrea Di Paolantonio,
  • Giulia Bisogni,
  • Salvatore Rossi,
  • Amelia Conte,
  • Francesca Madia and
  • Mario Sabatelli

Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other elementary lesions are frequently observed, configuring a series of different pathological pictures. In thi...

(This article belongs to the Special Issue Pathology of Peripheral Neuropathies )
  • Review
  • Open Access
6 Citations
6,033 Views
15 Pages

Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities

  • Gabriela Simionescu,
  • Ovidiu-Dumitru Ilie,
  • Alin Ciobica,
  • Bogdan Doroftei,
  • Radu Maftei,
  • Delia Grab,
  • Jack McKenna,
  • Nitasha Dhunna,
  • Ioannis Mavroudis and
  • Emil Anton

Both the gut-brain axis (GBA) and the hypothalamic–pituitary–adrenal (HPA) axis remain an intriguing yet obscure network with a strong influence over other systems of organs. Recent reports have sought to describe the multitude of harmful...

(This article belongs to the Special Issue Brain–Microbiome Interactions)
  • Article
  • Open Access
11 Citations
3,855 Views
13 Pages

HLA-DPB1*03 as Risk Allele and HLA-DPB1*04 as Protective Allele for Both Early- and Adult-Onset Multiple Sclerosis in a Hellenic Cohort

  • Maria Anagnostouli,
  • Artemios Artemiadis,
  • Maria Gontika,
  • Charalampos Skarlis,
  • Nikolaos Markoglou,
  • Serafeim Katsavos,
  • Konstantinos Kilindireas,
  • Ilias Doxiadis and
  • Leonidas Stefanis

Background: Human Leucocyte Antigens (HLA) represent the genetic loci most strongly linked to Multiple Sclerosis (MS). Apart from HLA-DR and HLA–DQ, HLA-DP alleles have been previously studied regarding their role in MS pathogenesis, but to a m...

(This article belongs to the Special Issue Advances in Multiple Sclerosis Research—Series I)
  • Article
  • Open Access
5 Citations
7,388 Views
11 Pages

Objectives: The aim of this study was to determine the influence of the sex of the therapist and of the athlete on the athlete’s current emotional state after a sports massage. The assumption was that the effect of a massage on the current mood...

(This article belongs to the Special Issue Depression and Anxiety: The Significance of Touch in Psychiatry—Clinical and Neuroscientific Approaches)
  • Case Report
  • Open Access
18 Citations
8,130 Views
12 Pages

Psychiatric Manifestation of Anti-LGI1 Encephalitis

  • Dominique Endres,
  • Harald Prüss,
  • Andrea Dressing,
  • Johanna Schneider,
  • Bernd Feige,
  • Tina Schweizer,
  • Nils Venhoff,
  • Kathrin Nickel,
  • Sophie Meixensberger and
  • Ludger Tebartz van Elst
  • + 5 authors

Background: Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis is typically characterized by limbic encephalitis, faciobrachial dystonic seizures and hyponatremia. The frequency with which milder forms of anti-LGI1 encephalitis mimic isolated...

  • Review
  • Open Access
38 Citations
9,291 Views
14 Pages

The population is aging in developed countries. This aging process results in many changes, both physical and mental. Over the years, there has been a gradual decline in the level of cognitive functions closely related to the ageing process, which is...

(This article belongs to the Section Molecular and Cellular Neuroscience)
  • Article
  • Open Access
21 Citations
5,605 Views
14 Pages

(1) Background: An unresolved phenomenon of insomnia disorder is a discrepancy between objectively measured sleep and subjective complaints. It has been shown that rapid eye movement (REM) sleep might be especially vulnerable to an altered perception...

(This article belongs to the Section Sleep and Circadian Neuroscience)
  • Article
  • Open Access
35 Citations
7,597 Views
16 Pages

Early Motor Development Predicts Clinical Outcomes of Siblings at High-Risk for Autism: Insight from an Innovative Motion-Tracking Technology

  • Angela Caruso,
  • Letizia Gila,
  • Francesca Fulceri,
  • Tommaso Salvitti,
  • Martina Micai,
  • Walter Baccinelli,
  • Maria Bulgheroni and
  • Maria Luisa Scattoni

Atypical motor patterns are potential early markers and predictors of later diagnosis of Autism Spectrum Disorder (ASD). This study aimed to investigate the early motor trajectories of infants at high-risk (HR) of ASD through MOVIDEA, a semi-automati...

(This article belongs to the Special Issue Advances in Autism Research)
  • Case Report
  • Open Access
7 Citations
3,655 Views
12 Pages

Background. An electroencephalogram (EEG) is a simple and widely used assessment tool that allows one to analyze the bioelectric activity of the brain. As a result, one can observe brain waves with different frequencies and amplitudes that correspond...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Editorial
  • Open Access
1 Citations
2,311 Views
2 Pages

The Special Issue “Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms” provides an excellent insight into the many facets of aneurysmal subarachnoid hemorrhage [...]

(This article belongs to the Special Issue Experimental and Clinical Treatment of Subarachnoid Hemorrhage after Rupture of Saccular Intracranial Aneurysms)
  • Case Report
  • Open Access
9 Citations
3,965 Views
5 Pages

Familial Hemiplegic Migraine with an ATP1A4 Mutation: Clinical Spectrum and Carbamazepine Efficacy

  • Giangennaro Coppola,
  • Grazia Maria Giovanna Pastorino,
  • Luigi Vetri,
  • Floriana D’Onofrio and
  • Francesca Felicia Operto

An Italian family with familial hemiplegic migraine (FHM) with the absence of mutations in the known genes associated with this disorder, namely ATP1A2, ATP1A3, CACNA1A, and SCN1A, has recently been reported. Soon afterward, whole exome sequencing al...

(This article belongs to the Special Issue Neurological Diseases in Children)
  • Article
  • Open Access
59 Citations
11,766 Views
17 Pages

Background: Severe collapsed disc secondary to degenerative spinal conditions leads to significant foraminal stenosis. We hypothesized that uniportal posterolateral transforaminal lumbar interbody fusion with endoscopic disc drilling technique could...

(This article belongs to the Special Issue Degenerative Spinal Disease)
  • Article
  • Open Access
5 Citations
4,804 Views
16 Pages

Postnatal Guinea Pig Brain Development, as Revealed by Magnetic Resonance and Diffusion Kurtosis Imaging

  • Roger J. Mullins,
  • Su Xu,
  • Jiachen Zhuo,
  • Steve Roys,
  • Edna F.R. Pereira,
  • Edson X. Albuquerque and
  • Rao P. Gullapalli

This study used in vivo magnetic resonance imaging (MRI) to identify age dependent brain structural characteristics in Dunkin Hartley guinea pigs. Anatomical T2-weighted images, diffusion kurtosis (DKI) imaging, and T2 relaxometry measures were acqui...

(This article belongs to the Section Developmental Neuroscience)
  • Article
  • Open Access
7 Citations
3,614 Views
27 Pages

Background and Objectives: Raw electroencephalographic (EEG) signals are rarely used to monitor the depth of volatile induction of general anaesthesia (VIGA) with sevoflurane, even though EEG-based indices may show aberrant values. We aimed to identi...

  • Review
  • Open Access
36 Citations
9,365 Views
24 Pages

For social animals that communicate acoustically, hearing loss and social isolation are factors that independently influence social behavior. In human subjects, hearing loss may also contribute to objective and subjective measures of social isolation...

(This article belongs to the Special Issue Central Auditory Plasticity)
  • Review
  • Open Access
128 Citations
35,300 Views
20 Pages

The Effects of the Early Start Denver Model for Children with Autism Spectrum Disorder: A Meta-Analysis

  • Elizabeth A. Fuller,
  • Kelsey Oliver,
  • Sarah F. Vejnoska and
  • Sally J. Rogers

This meta-analysis examined the effects of the Early Start Denver Model (ESDM) for young children with autism on developmental outcome measures. The 12 included studies reported results from 640 children with autism across 44 unique effect sizes. The...

(This article belongs to the Special Issue Advances in Autism Research)
  • Review
  • Open Access
40 Citations
12,457 Views
19 Pages

Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection

  • Gloria Ortiz-Guerrero,
  • Rodrigo E. Gonzalez-Reyes,
  • Alejandra de-la-Torre,
  • German Medina-Rincón and
  • Mauricio O. Nava-Mesa

Toxoplasma gondii is an obligate intracellular parasite considered one of the most successful pathogens in the world, owing to its ability to produce long-lasting infections and to persist in the central nervous system (CNS) in most warm-blooded anim...

(This article belongs to the Special Issue Neuropathology of Alzheimer’s Disease)
  • Article
  • Open Access
10 Citations
3,165 Views
10 Pages

Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked po...

  • Article
  • Open Access
19 Citations
5,025 Views
22 Pages

Extensive Evaluation of Morphological Statistical Harmonization for Brain Age Prediction

  • Angela Lombardi,
  • Nicola Amoroso,
  • Domenico Diacono,
  • Alfonso Monaco,
  • Sabina Tangaro and
  • Roberto Bellotti

Characterizing both neurodevelopmental and aging brain structural trajectories is important for understanding normal biological processes and atypical patterns that are related to pathological phenomena. Initiatives to share open access morphological...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Article
  • Open Access
6 Citations
4,150 Views
12 Pages

Blood-Based Biomarkers Predictive of Metformin Target Engagement in Fragile X Syndrome

  • Mittal Jasoliya,
  • Heather Bowling,
  • Ignacio Cortina Petrasic,
  • Blythe Durbin-Johnson,
  • Eric Klann,
  • Aditi Bhattacharya,
  • Randi Hagerman and
  • Flora Tassone

Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predic...

  • Article
  • Open Access
32 Citations
11,481 Views
17 Pages

Characterizing Olfactory Function in Children with Autism Spectrum Disorder and Children with Sensory Processing Dysfunction

  • Julia R. Sweigert,
  • Tanya St. John,
  • Kristin Kawena Begay,
  • Greg E. Davis,
  • Jeffrey Munson,
  • Eric Shankland,
  • Annette Estes,
  • Stephen R. Dager and
  • Natalia M. Kleinhans

Abnormalities in olfactory function have been identified in a number of neurological and psychiatric disorders, including Parkinson’s disease and schizophrenia. However, little is known about olfactory function in autism spectrum disorder (ASD)...

  • Article
  • Open Access
18 Citations
5,407 Views
9 Pages

Microdiscectomy for the upward migration of upper lumbar herniated discs has a high risk of isthmus and facet injury. Fully endoscopic transforaminal discectomy can preserve normal bony structures during discectomy. The purpose of this study was to a...

(This article belongs to the Special Issue Degenerative Spinal Disease)
  • Case Report
  • Open Access
2 Citations
4,678 Views
6 Pages

Intracranial pseudoaneurysms (PSA) are scarcely presented in the literature. We describe the case of an intracranial PSA on the right anterior cerebral artery, which developed during the complicated surgical treatment of a ruptured right middle cereb...

(This article belongs to the Special Issue Neurosurgery for Cerebral Aneurysms)
  • Article
  • Open Access
5 Citations
6,452 Views
12 Pages

Stress can modulate episodic memory in various ways. The present study asks how post-encoding stress affects visual context memory. Participants encoded object images centrally positioned on background scenes. After encoding, they were either exposed...

(This article belongs to the Special Issue The Role of Stress and Glucocorticoids in Learning and Memory)
  • Article
  • Open Access
26 Citations
22,142 Views
15 Pages

Migraine Frequency Decrease Following Prolonged Medical Cannabis Treatment: A Cross-Sectional Study

  • Joshua Aviram,
  • Yelena Vysotski,
  • Paula Berman,
  • Gil M. Lewitus,
  • Elon Eisenberg and
  • David Meiri

Background: Medical cannabis (MC) treatment for migraine is practically emerging, although sufficient clinical data are not available for this indication. This cross-sectional questionnaire-based study aimed to investigate the associations between ph...

(This article belongs to the Special Issue Cannabis: Neuropsychiatry and Its Effects on Brain and Behavior)
  • Article
  • Open Access
11 Citations
4,780 Views
12 Pages

Leber’s hereditary optic neuropathy (LHON) is one of the mitochondrial diseases that causes loss of central vision, progressive impairment and subsequent degeneration of retinal ganglion cells (RGCs). In recent years, diffusion tensor imaging (...

(This article belongs to the Special Issue Mitochondria as Therapeutic Target for Acute Brain Pathologies)

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