Appl. Sci. 2013, 3(2), 457-468; doi:10.3390/app3020457

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

1 Research Group of Heterocyclic Compounds, Chemistry Program, Faculty of Basic Sciences, The University of Atlantico, Km 7 Antigua vía Puerto Colombia, Barranquilla-Atlántico, Colombia 2 Research Group of Heterocyclic Compounds, Department of Chemistry, University of Valle, A. A 25360 Cali, Colombia 3 Department of Inorganic and Organic Chemistry, University of Jaén, 23071 Jaén, Spain
* Author to whom correspondence should be addressed.
Received: 31 January 2013; in revised form: 26 February 2013 / Accepted: 27 March 2013 / Published: 16 April 2013
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
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Abstract: A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
Keywords: pyrazolines; cyclocondensation; sonication; chalcones; hydrazines

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MDPI and ACS Style

Trilleras, J.; Polo, E.; Quiroga, J.; Cobo, J.; Nogueras, M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Appl. Sci. 2013, 3, 457-468.

AMA Style

Trilleras J, Polo E, Quiroga J, Cobo J, Nogueras M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Applied Sciences. 2013; 3(2):457-468.

Chicago/Turabian Style

Trilleras, Jorge; Polo, Efraín; Quiroga, Jairo; Cobo, Justo; Nogueras, Manuel. 2013. "Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives." Appl. Sci. 3, no. 2: 457-468.

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