Abstract: A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
Keywords: pyrazolines; cyclocondensation; sonication; chalcones; hydrazines
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Trilleras, J.; Polo, E.; Quiroga, J.; Cobo, J.; Nogueras, M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Appl. Sci. 2013, 3, 457-468.
Trilleras J, Polo E, Quiroga J, Cobo J, Nogueras M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Applied Sciences. 2013; 3(2):457-468.
Trilleras, Jorge; Polo, Efraín; Quiroga, Jairo; Cobo, Justo; Nogueras, Manuel. 2013. "Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives." Appl. Sci. 3, no. 2: 457-468.