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Appl. Sci. 2013, 3(2), 457-468; doi:10.3390/app3020457
Article

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

1
, 1
, 2
, 3
 and 3,*
1 Research Group of Heterocyclic Compounds, Chemistry Program, Faculty of Basic Sciences, The University of Atlantico, Km 7 Antigua vía Puerto Colombia, Barranquilla-Atlántico, Colombia 2 Research Group of Heterocyclic Compounds, Department of Chemistry, University of Valle, A. A 25360 Cali, Colombia 3 Department of Inorganic and Organic Chemistry, University of Jaén, 23071 Jaén, Spain
* Author to whom correspondence should be addressed.
Received: 31 January 2013 / Revised: 26 February 2013 / Accepted: 27 March 2013 / Published: 16 April 2013
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
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Abstract

A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
Keywords: pyrazolines; cyclocondensation; sonication; chalcones; hydrazines pyrazolines; cyclocondensation; sonication; chalcones; hydrazines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Trilleras, J.; Polo, E.; Quiroga, J.; Cobo, J.; Nogueras, M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Appl. Sci. 2013, 3, 457-468.

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