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Appl. Sci. 2013, 3(2), 457-468; doi:10.3390/app3020457
Article

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

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Received: 31 January 2013; in revised form: 26 February 2013 / Accepted: 27 March 2013 / Published: 16 April 2013
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
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Abstract: A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
Keywords: pyrazolines; cyclocondensation; sonication; chalcones; hydrazines pyrazolines; cyclocondensation; sonication; chalcones; hydrazines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Trilleras, J.; Polo, E.; Quiroga, J.; Cobo, J.; Nogueras, M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Appl. Sci. 2013, 3, 457-468.

AMA Style

Trilleras J, Polo E, Quiroga J, Cobo J, Nogueras M. Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives. Applied Sciences. 2013; 3(2):457-468.

Chicago/Turabian Style

Trilleras, Jorge; Polo, Efraín; Quiroga, Jairo; Cobo, Justo; Nogueras, Manuel. 2013. "Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives." Appl. Sci. 3, no. 2: 457-468.


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