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A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80
Department of Radiology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA
Department of Chemistry, Virginia Tech, 1109 Hahn Hall, Blacksburg, VA 24061, USA
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA
* Author to whom correspondence should be addressed.
Received: 9 February 2012; in revised form: 2 May 2012 / Accepted: 3 May 2012 / Published: 10 May 2012
Abstract: The current report describes the development of a dual modality tomographic agent for both positron emission tomography and magnetic resonance imaging (PET/MRI). The dual-modality agent in this study was based on a 124I (PET) radiolabeled tri-gadolinium endohedral metallofullerene Gd3N@C80 (MRI) nanoprobe platform. The outer surface of the fullerene cage of the Gd3N@C80 metallofullerenes was surface functionalized with carboxyl and hydroxyl groups (f-Gd3N@C80) using previously developed procedures and subsequently iodinated with 124I to produce 124I-f-Gd3N@C80 nanoprobe. Orthotopic tumor-bearing rats were infused intratumorally by convection-enhanced delivery (CED) with the 124I-f-Gd3N@C80 agent and imaged by MRI or micro PET. The anatomical positioning and distribution of the 124I-f-Gd3N@C80 agent were comparable between the MRI and PET scans. The 124I-f-Gd3N@C80 dual-agent distribution and infusion site within the tumor was clearly evident in both T1- and T2-weighted MR images. The results demonstrate the successful preparation of a dual-modality imaging agent, 124I-f-Gd3N@C80, which could ultimately be used for simultaneous PET/MR imaging.
Keywords: PET; MRI; metallofullerene; iodination
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MDPI and ACS Style
Luo, J.; Wilson, J.D.; Zhang, J.; Hirsch, J.I.; Dorn, H.C.; Fatouros, P.P.; Shultz, M.D. A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80. Appl. Sci. 2012, 2, 465-478.
Luo J, Wilson JD, Zhang J, Hirsch JI, Dorn HC, Fatouros PP, Shultz MD. A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80. Applied Sciences. 2012; 2(2):465-478.
Luo, Jianqiao; Wilson, John D.; Zhang, Jianyuan; Hirsch, Jerry I.; Dorn, Harry C.; Fatouros, Panos P.; Shultz, Michael D. 2012. "A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80." Appl. Sci. 2, no. 2: 465-478.