Appl. Sci. 2012, 2(2), 465-478; doi:10.3390/app2020465

A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80

1 Department of Radiology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA 2 Department of Chemistry, Virginia Tech, 1109 Hahn Hall, Blacksburg, VA 24061, USA 3 Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298, USA
* Author to whom correspondence should be addressed.
Received: 9 February 2012; in revised form: 2 May 2012 / Accepted: 3 May 2012 / Published: 10 May 2012
(This article belongs to the Special Issue Magnetic Nanoparticles: Synthesis, Properties and Applications)
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Abstract: The current report describes the development of a dual modality tomographic agent for both positron emission tomography and magnetic resonance imaging (PET/MRI). The dual-modality agent in this study was based on a 124I (PET) radiolabeled tri-gadolinium endohedral metallofullerene Gd3N@C80 (MRI) nanoprobe platform. The outer surface of the fullerene cage of the Gd3N@C80 metallofullerenes was surface functionalized with carboxyl and hydroxyl groups (f-Gd3N@C80) using previously developed procedures and subsequently iodinated with 124I to produce 124I-f-Gd3N@C80 nanoprobe. Orthotopic tumor-bearing rats were infused intratumorally by convection-enhanced delivery (CED) with the 124I-f-Gd3N@C80 agent and imaged by MRI or micro PET. The anatomical positioning and distribution of the 124I-f-Gd3N@C80 agent were comparable between the MRI and PET scans. The 124I-f-Gd3N@C80­ dual-agent distribution and infusion site within the tumor was clearly evident in both T1- and T2-weighted MR images. The results demonstrate the successful preparation of a dual-modality imaging agent, 124I-f-Gd3N@C80, which could ultimately be used for simultaneous PET/MR imaging.
Keywords: PET; MRI; metallofullerene; iodination

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MDPI and ACS Style

Luo, J.; Wilson, J.D.; Zhang, J.; Hirsch, J.I.; Dorn, H.C.; Fatouros, P.P.; Shultz, M.D. A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80. Appl. Sci. 2012, 2, 465-478.

AMA Style

Luo J, Wilson JD, Zhang J, Hirsch JI, Dorn HC, Fatouros PP, Shultz MD. A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80. Applied Sciences. 2012; 2(2):465-478.

Chicago/Turabian Style

Luo, Jianqiao; Wilson, John D.; Zhang, Jianyuan; Hirsch, Jerry I.; Dorn, Harry C.; Fatouros, Panos P.; Shultz, Michael D. 2012. "A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80." Appl. Sci. 2, no. 2: 465-478.

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