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Facilitation of Relational Learning in Schizophrenia
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
Department of Psychology, University of Connecticut Waterbury, 99 East Main Street Waterbury, CT 06702, USA
Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA
* Author to whom correspondence should be addressed.
Received: 15 February 2013; in revised form: 25 March 2013 / Accepted: 26 March 2013 / Published: 12 April 2013
Abstract: Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training.
Keywords: schizophrenia; relational learning; training; transverse patterning; hippocampus; medial temporal lobe; memory
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Spieker, E.A.; Griego, J.A.; Astur, R.S.; Holcomb, H.H.; Rowland, L.M. Facilitation of Relational Learning in Schizophrenia. Behav. Sci. 2013, 3, 206-216.
Spieker EA, Griego JA, Astur RS, Holcomb HH, Rowland LM. Facilitation of Relational Learning in Schizophrenia. Behavioral Sciences. 2013; 3(2):206-216.
Spieker, Elena A.; Griego, Jacqueline A.; Astur, Robert S.; Holcomb, Henry H.; Rowland, Laura M. 2013. "Facilitation of Relational Learning in Schizophrenia." Behav. Sci. 3, no. 2: 206-216.