Behav. Sci. 2013, 3(2), 206-216; doi:10.3390/bs3020206

Facilitation of Relational Learning in Schizophrenia

1email, 1email, 2email, 1,3email and 1,4,* email
Received: 15 February 2013; in revised form: 25 March 2013 / Accepted: 26 March 2013 / Published: 12 April 2013
(This article belongs to the Special Issue Learning and Memory Deficits Related to Neuropsychiatric Disorders)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training.
Keywords: schizophrenia; relational learning; training; transverse patterning; hippocampus; medial temporal lobe; memory
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MDPI and ACS Style

Spieker, E.A.; Griego, J.A.; Astur, R.S.; Holcomb, H.H.; Rowland, L.M. Facilitation of Relational Learning in Schizophrenia. Behav. Sci. 2013, 3, 206-216.

AMA Style

Spieker EA, Griego JA, Astur RS, Holcomb HH, Rowland LM. Facilitation of Relational Learning in Schizophrenia. Behavioral Sciences. 2013; 3(2):206-216.

Chicago/Turabian Style

Spieker, Elena A.; Griego, Jacqueline A.; Astur, Robert S.; Holcomb, Henry H.; Rowland, Laura M. 2013. "Facilitation of Relational Learning in Schizophrenia." Behav. Sci. 3, no. 2: 206-216.

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