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Med. Sci. 2014, 2(1), 1-22; doi:10.3390/medsci2010001

Antitumor Immunity and Dietary Compounds

1
Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
2
Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
3
Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
*
Author to whom correspondence should be addressed.
Received: 15 November 2013 / Revised: 16 December 2013 / Accepted: 16 December 2013 / Published: 27 December 2013
(This article belongs to the Special Issue Recent Advances in Cellular Immunotherapy)
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Abstract

The mechanisms by which natural dietary compounds exert their antitumor effects have been the focus of a large number of research efforts in recent years. Induction of apoptosis by inhibition of cell proliferative pathways is one of the common means of cell death employed by these dietary compounds. However, agents that can activate an antitumor immune response in addition to a chemotherapeutic effect may be useful adjuvants or alternative therapies for the treatment of cancer. The focus of this review is to highlight representative dietary compounds, namely Withania somnifera, Panax ginseng, curcumin and resveratrol with special emphasis on their antitumor immune mechanism of action. Each of these dietary compounds and their sources has a history of safe human use as food or in herbal medicine traditions, potentially making them ideal therapeutics. Here we report the recent advances in the cellular immune mechanisms utilized by these compounds to induce antitumor immunity. Taken together, these findings provide a new perspective for exploiting novel dietary compounds as chemoimmunotherapeutic anti-cancer agents. View Full-Text
Keywords: antitumor immunity; natural products; immunomodulation; cancer; Withania somnifera; Panax ginseng; curcumin; resveratrol antitumor immunity; natural products; immunomodulation; cancer; Withania somnifera; Panax ginseng; curcumin; resveratrol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Smith, A.R.; Andreansky, S. Antitumor Immunity and Dietary Compounds. Med. Sci. 2014, 2, 1-22.

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