Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation
Abstract
:1. Introduction
2. Fibroblast Growth Factors (FGFs) are Multi-Functional Growth Factors
3. Signal Transduction of FGF and FGFR
4. Role of FGF and FGFR in Tumorigenesis, Tumor Angiogenesis, and Inflammation
5. Integrin-Growth Factor Receptor Crosstalk
Growth factor | Integrins | References |
---|---|---|
Angiopoietin-1 | α5β1 | [68] |
Angiopoietin-2 | α5β1, β2 | [68,69] |
CD40 ligand | αIIbβ3, α5β1, αMβ2 | [70,71,72] |
FGF-1 | αvβ3 | [10] |
FGF-2 | αvβ3 | [73] |
Fractalkine | αvβ3, α4β1 | [74] |
Pro HB-EGF | α3β1 | [75] |
IGF-1 | αvβ3, α6β4 | [60,61] |
LTGF-β | α6β4, αvβ8 | [66,67] |
Neuregulin-1 | αvβ3, α6β4 | [62] |
NGF | α9β1 | [76] |
NT3 | α9β1 | [76] |
Semaphorin 7A | α1β1 | [77] |
VEGF-A | α3β1 | [64] |
VEGF-C | α9β1 | [63] |
VEGF-D | α9β1 | [63] |
6. Crosstalk between Integrin αvβ3 and FGFR through Direct Binding to FGF
7. R50E Is a Dominant-Negative Antagonist of FGFR
8. Potential Advantage of R50E over Antibodies and Kinase Inhibitors
9. Can Mutant Human Protein Be Used As a Therapeutic Agent?
10. Targeting and Delivery of R50E to Cancer
11. Conclusions
Acknowledgments
Conflict of Interest
References
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Mori, S.; Takada, Y. Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation. Med. Sci. 2013, 1, 20-36. https://doi.org/10.3390/medsci1010020
Mori S, Takada Y. Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation. Medical Sciences. 2013; 1(1):20-36. https://doi.org/10.3390/medsci1010020
Chicago/Turabian StyleMori, Seiji, and Yoshikazu Takada. 2013. "Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation" Medical Sciences 1, no. 1: 20-36. https://doi.org/10.3390/medsci1010020