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Signs Observed Among Animal Species Infected with Raccoon Rabies Variant Virus, Massachusetts, USA, 1992–2010
Animals 2011, 1(4), 402-413; doi:10.3390/ani1040402

Investigation of an Imported Case of Rabies in a Juvenile Dog with Atypical Presentation

1,* , 2
Received: 8 October 2011 / Revised: 2 November 2011 / Accepted: 15 November 2011 / Published: 18 November 2011
(This article belongs to the Special Issue Zoonotic Diseases of Companion Animals)
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Movement of dogs between rabies-endemic and rabies-free countries carries the inherent risk of introducing the disease. In April of 2008, a juvenile dog was imported to the UK from Sri Lanka. It died shortly after transfer to a quarantine facility in the south-east of England following a short history of diarrhoea and convulsions but no overt signs of aggression. Subsequent investigation confirmed that rabies was the cause of death. Rabies virus was isolated from brain samples taken from the dog and the subsequent phylogenetic investigation confirmed that the genomic sequence from this virus shared over 99% homology with endemic rabies viruses from Sri Lanka. Histological examination of the brain demonstrated clear signs of encephalitis and rabies antigenic labeling in numerous neurons. In this particular case, Negri bodies were absent. As this case was diagnosed in a quarantine facility, the ‘rabies-free’ status of the UK was un-affected.
Keywords: rabies virus; dog; quarantine; Sri Lanka rabies virus; dog; quarantine; Sri Lanka
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Johnson, N.; Nunez, A.; Marston, D.A.; Harkess, G.; Voller, K.; Goddard, T.; Hicks, D.; McElhinney, L.M.; Fooks, A.R. Investigation of an Imported Case of Rabies in a Juvenile Dog with Atypical Presentation. Animals 2011, 1, 402-413.

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