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Microorganisms 2017, 5(1), 1; doi:10.3390/microorganisms5010001

Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products

1
Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan
2
Food Science Research Laboratories, Meiji Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Haruki Kitazawa and Julio Villena
Received: 21 October 2016 / Revised: 19 December 2016 / Accepted: 19 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue Probiotic Microorganisms: An Intimate Gaze)
View Full-Text   |   Download PDF [1304 KB, uploaded 23 December 2016]   |  

Abstract

Lactic acid bacteria (LAB) form a major component of gut microbiota and are often used as probiotics for fermented foods, such as yoghurt. In this study, we aimed to evaluate immunomodulatory activity of LAB, especially that of Lactobacillus bulgaricus ME-552 (ME552) and Streptococcus thermophilus ME-553 (ME553). In vivo/in vitro assay was performed in order to investigate their effects on T cell function. After oral administration of ME553 to C57BL/6 mice, the amount of both interferon γ (IFN-γ) and interleukin 17 (IL-17) produced by cluster of differentiation (CD) 4+ T cells from Peyer’s patches (PPs) were significantly enhanced. On the other hand, ME552 only up-regulated the production of IL-17 from PP cells. The extent of induction for IFN-γ production differed between ME552 and ME553. These results suggest that LAB modulate T cell effector functions and mucosal immunity. View Full-Text
Keywords: Lactic acid bacteria; Peyer’s patches; Dendritic cells; T helper cells; Lactobacillus bulgaricus; Streptococcus thermophilus; Interferon γ; Interleukin 17; Mucosal immunity; Probiotics Lactic acid bacteria; Peyer’s patches; Dendritic cells; T helper cells; Lactobacillus bulgaricus; Streptococcus thermophilus; Interferon γ; Interleukin 17; Mucosal immunity; Probiotics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kamiya, T.; Watanabe, Y.; Makino, S.; Kano, H.; Tsuji, N.M. Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products. Microorganisms 2017, 5, 1.

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