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Microorganisms 2016, 4(1), 16; doi:10.3390/microorganisms4010016

Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome

1
Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
2
Inserm UMR 1149, UFR de Médecine Paris Diderot, Université Paris Diderot, Sorbonne Paris Cité, DHU Unit, APHP, F-75890 Paris, France
3
Université Pierre et Marie Curie and Department of Endocrine and Oncologic Biochemistry, APHP La Pitié-Salpêtrière Hospital,73013 Paris, France
4
Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France
*
Author to whom correspondence should be addressed.
Academic Editor: Carl Gordon Johnston
Received: 20 January 2016 / Revised: 22 February 2016 / Accepted: 2 March 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Host-Gut Microbiota Metabolic Interactions)
View Full-Text   |   Download PDF [547 KB, uploaded 8 March 2016]   |  

Abstract

Extensive resection of small bowel often leads to short bowel syndrome (SBS). SBS patients develop clinical mal-absorption and dehydration relative to the reduction of absorptive area, acceleration of gastrointestinal transit time and modifications of the gastrointestinal intra-luminal environment. As a consequence of severe mal-absorption, patients require parenteral nutrition (PN). In adults, the overall adaptation following intestinal resection includes spontaneous and complex compensatory processes such as hyperphagia, mucosal remodeling of the remaining part of the intestine and major modifications of the microbiota. SBS patients, with colon in continuity, harbor a specific fecal microbiota that we called “lactobiota” because it is enriched in the Lactobacillus/Leuconostoc group and depleted in anaerobic micro-organisms (especially Clostridium and Bacteroides). In some patients, the lactobiota-driven fermentative activities lead to an accumulation of fecal d/l-lactates and an increased risk of d-encephalopathy. Better knowledge of clinical parameters and lactobiota characteristics has made it possible to stratify patients and define group at risk for d-encephalopathy crises. View Full-Text
Keywords: mal-absorption; dysbiosis; colon; surgery; lactate mal-absorption; dysbiosis; colon; surgery; lactate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mayeur, C.; Gillard, L.; Le Beyec, J.; Bado, A.; Joly, F.; Thomas, M. Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome. Microorganisms 2016, 4, 16.

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