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Microorganisms 2016, 4(1), 15; doi:10.3390/microorganisms4010015

Metabolic Interaction of Helicobacter pylori Infection and Gut Microbiota

Departments of Pediatrics, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, #138 Sheng Li Road, Tainan 70428, Taiwan
Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan
Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, #138 Sheng Li Road, Tainan 70428, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Carl Gordon Johnston
Received: 6 August 2015 / Revised: 2 December 2015 / Accepted: 5 February 2016 / Published: 16 February 2016
(This article belongs to the Special Issue Host-Gut Microbiota Metabolic Interactions)
View Full-Text   |   Download PDF [566 KB, uploaded 16 February 2016]   |  


As a barrier, gut commensal microbiota can protect against potential pathogenic microbes in the gastrointestinal tract. Crosstalk between gut microbes and immune cells promotes human intestinal homeostasis. Dysbiosis of gut microbiota has been implicated in the development of many human metabolic disorders like obesity, hepatic steatohepatitis, and insulin resistance in type 2 diabetes (T2D). Certain microbes, such as butyrate-producing bacteria, are lower in T2D patients. The transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome, but the exact pathogenesis remains unclear. H. pylori in the human stomach cause chronic gastritis, peptic ulcers, and gastric cancers. H. pylori infection also induces insulin resistance and has been defined as a predisposing factor to T2D development. Gastric and fecal microbiota may have been changed in H. pylori-infected persons and mice to promote gastric inflammation and specific diseases. However, the interaction of H. pylori and gut microbiota in regulating host metabolism also remains unknown. Further studies aim to identify the H. pylori-microbiota-host metabolism axis and to test if H. pylori eradication or modification of gut microbiota can improve the control of human metabolic disorders. View Full-Text
Keywords: H. pylori; microbiota; metabolic interaction; insulin resistant; diabetes H. pylori; microbiota; metabolic interaction; insulin resistant; diabetes

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Yang, Y.-J.; Sheu, B.-S. Metabolic Interaction of Helicobacter pylori Infection and Gut Microbiota. Microorganisms 2016, 4, 15.

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