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Microorganisms 2016, 4(2), 20; doi:10.3390/microorganisms4020020

Microbiome, Metabolome and Inflammatory Bowel Disease

1
Department of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA
2
Department of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Carl Gordon Johnston
Received: 9 March 2016 / Revised: 25 May 2016 / Accepted: 6 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue Host-Gut Microbiota Metabolic Interactions)
View Full-Text   |   Download PDF [493 KB, uploaded 15 June 2016]   |  

Abstract

Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn’s Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis. View Full-Text
Keywords: microbiome; metabolome; metabolites; dysbiosis; inflammation bowel diseases; prebiotics; probiotics microbiome; metabolome; metabolites; dysbiosis; inflammation bowel diseases; prebiotics; probiotics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ahmed, I.; Roy, B.C.; Khan, S.A.; Septer, S.; Umar, S. Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms 2016, 4, 20.

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