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Pathogens 2017, 6(3), 28; doi:10.3390/pathogens6030028

Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency

Van Andel Research Institute, Grand Rapids, MI 49503, USA
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Received: 25 May 2017 / Accepted: 6 June 2017 / Published: 23 June 2017
(This article belongs to the Special Issue Herpesviruses)
View Full-Text   |   Download PDF [229 KB, uploaded 26 June 2017]

Abstract

All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent infection provide valuable insight on the host processes regulating viral establishment and maintenance of latency. More robust and rapid than infections in live animal studies, advancements in neuronal culture techniques have made the systematic analysis of viral reactivation mechanisms feasible. Only recently have human neuronal cell lines been available, but models in the natural host cell are a critical addition to the currently available models. View Full-Text
Keywords: latent infection; lytic infection; HSV-1; HSV-2; neuron; quiescent infection; cell culture latent infection; lytic infection; HSV-1; HSV-2; neuron; quiescent infection; cell culture
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Thellman, N.M.; Triezenberg, S.J. Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency. Pathogens 2017, 6, 28.

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